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本文引用的文献

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Association of CYP1A1 MspI polymorphism in the esophageal cancer risk: a meta-analysis in the Chinese population.CYP1A1基因MspI多态性与食管癌风险的关联：中国人群的一项荟萃分析
Eur J Med Res. 2015 Mar 30;20(1):46. doi: 10.1186/s40001-015-0135-3.
2
Association of polymorphisms in X-ray repair cross complementing 1 gene and risk of esophageal squamous cell carcinoma in a Chinese population.X射线修复交叉互补基因1多态性与中国人群食管鳞状细胞癌风险的关联。
Biomed Res Int. 2015;2015:509215. doi: 10.1155/2015/509215. Epub 2015 Feb 1.
3
Association of the genetic polymorphisms in XRCC6 and XRCC5 with the risk of ESCC in a high-incidence region of North China.华北高发地区XRCC6和XRCC5基因多态性与食管癌风险的关联
Tumori. 2015 Jan-Feb;101(1):24-9. doi: 10.5301/tj.5000206. Epub 2015 Feb 17.
4
Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis.乙醛脱氢酶2基因Glu504Lys多态性与癌症风险的关联：一项荟萃分析。
PLoS One. 2015 Feb 13;10(2):e0117173. doi: 10.1371/journal.pone.0117173. eCollection 2015.
5
Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α.胃癌易感基因IL-10 - 1082和TNF-α的临床研究
Genet Mol Res. 2014 Dec 19;13(4):10909-12. doi: 10.4238/2014.December.19.12.
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Interleukin-10 (IL-10) promoter genotypes are associated with lung cancer risk in Taiwan males and smokers.白细胞介素-10（IL-10）启动子基因型与台湾男性和吸烟者的肺癌风险相关。
Anticancer Res. 2014 Dec;34(12):7039-44.
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J Int Med Res. 2014 Dec;42(6):1193-201. doi: 10.1177/0300060514544388. Epub 2014 Oct 3.
9
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Joint effects of smoking and alcohol drinking on esophageal cancer mortality in Japanese men: findings from the Japan collaborative cohort study.吸烟与饮酒对日本男性食管癌死亡率的联合影响：来自日本协作队列研究的结果
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白细胞介素-10基因多态性在食管癌易感性中的作用及其与环境因素的关联。

Role of IL-10 gene polymorphisms on the susceptibility for esophageal cancer and its association with environmental factors.

作者信息

Yang Yingtao, Fa Xianen

机构信息

The Second Affiliated Hospital of Zhengzhou University Zhengzhou, China ; The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou, China.

The Second Affiliated Hospital of Zhengzhou University Zhengzhou, China.

出版信息

Int J Clin Exp Pathol. 2015 Aug 1;8(8):9580-5. eCollection 2015.

PMID:26464722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4583954/
Abstract

We conducted a hospital-based case-control study to investigate the association of three common SNPs (-1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) of IL-10 gene polymorphisms with the susceptibility to esophageal cancer in a Chinese population. 246 patients with pathologically proven esophageal cancer and 492 healthy control subjects were collected in our study. Genotyping of IL-10-1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872 was performed using the Sequenom MassARRAY platform (Sequenom; San Diego, CA). Unconditional logistic regression analyses showed that subjects carrying the AA genotype and GA+AA genotype of IL-10-1082G/A rs1800896 were associated with an increased risk of esophageal cancer, and the adjusted ORs (95% CI) were 2.19 (1.31-3.64) and 1.44 (1.05-1.99), respectively. However, we did not find significant association of IL-10-819T/C rs1800871 and -592A/C rs1800872 with the development of esophageal cancer. By stratification analysis, we found that IL-10-1082G/A rs1800896 polymorphism has no significant association with smoking, drinking and family history of cancer in the first relatives in esophageal cancer risk (P>0.05). In conclusion, IL-10-1082G/A rs1800896 genetic variation may be employed as candidate biomarkers for the prediction of susceptibility in esophageal cancer.

摘要

我们开展了一项基于医院的病例对照研究，以调查白细胞介素-10（IL-10）基因多态性的三个常见单核苷酸多态性（SNP）（-1082G/A rs1800896、-819T/C rs1800871和-592A/C rs1800872）与中国人群食管癌易感性之间的关联。本研究收集了246例经病理证实的食管癌患者和492例健康对照者。使用Sequenom MassARRAY平台（Sequenom；加利福尼亚州圣地亚哥）对IL-10 -1082G/A rs1800896、-819T/C rs1800871和-592A/C rs1800872进行基因分型。非条件逻辑回归分析显示，携带IL-10 -1082G/A rs1800896的AA基因型和GA + AA基因型的受试者患食管癌的风险增加，校正后的比值比（95%可信区间）分别为2.19（1.31 - 3.64）和1.44（1.05 - 1.99）。然而，我们未发现IL-10 -819T/C rs1800871和-592A/C rs1800872与食管癌发生之间存在显著关联。通过分层分析，我们发现IL-10 -1082G/A rs1800896多态性与吸烟、饮酒以及食管癌风险中一级亲属的癌症家族史无显著关联（P>0.05）。总之，IL-10 -1082G/A rs1800896基因变异可作为预测食管癌易感性的候选生物标志物。