π-扩展给体-受体卟啉和金属卟啉用于抗菌光动力失活。
π-Extended Donor-Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation.
机构信息
Center for Soft Nanoscience, Westfälische Wilhelms-Universität Münster, Busso-Peus-Straße 10, 48149, Münster, Germany.
Wydział Chemii, Uniwersytet Wrocławski, ul. F. Joliot-Curie 14, 50383, Wrocław, Poland.
出版信息
Chemistry. 2020 Jul 2;26(37):8262-8266. doi: 10.1002/chem.201905372. Epub 2020 Jun 8.
Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.
游离碱、锌和钯的π-扩展卟啉，其中含有并合的萘二酰胺单元，被用作抗菌光动力疗法（aPDT）中的光敏剂。通过对革兰氏阳性菌的光物理和体外光生物学研究评估了它们的功效，发现其功效取决于金属配位，钯配合物的光敏活性显著增强。
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