Rastović Marina, Srdić-Galić Biljana, Barak Otto, Stokić Edita, Polovina Snežana
1Subotica General Hospital, Department of Internal Medicine, Division of Endocrinology, Subotica, Serbia; 2University of Novi Sad, Faculty of Medicine, Department of Anatomy, Novi Sad, Serbia; 3University of Novi Sad, Faculty of Medicine, Department of Physiology, Novi Sad, Serbia; 4University of Novi Sad, Faculty of Medicine, Institute of Internal Disease, Department of Endocrinology, Diabetes and Metabolic Disorders, Novi Sad, Serbia; 5Clinical Center of Serbia, Department of Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia; 6University of Novi Sad, Faculty of Pharmacy, Department of Internal Medicine, Novi Sad, Serbia.
Acta Clin Croat. 2019 Sep;58(3):430-438. doi: 10.20471/acc.2019.58.03.05.
The relationship between aging and changes in heart rate variability (HRV) could depend on the metabolic profile of obese people, i.e. metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). We aimed to determine the age at which obesity related autonomic dysfunction becomes significant and whether it decreases differently according to metabolic profile. We analyzed HRV in 99 adults using Wildman's criteria for metabolic profile and 5-minute HRV for autonomic nervous system. In MHO, high frequency (HF) decreased in the 4 decade of life. In MUO, standard deviation of R-R intervals (SDNN), root mean square of successive differences of all R-R intervals (RMSSD), number of adjacent intervals differing by more than 50 ms expressed as percentage of all intervals in the collecting period (pNN50), HF, low frequency (LF), LF/HF (LF divided by HF) and total power (TP) decreased in the 4 decade of life (partial shared variance 28%-36%). In conclusion, an age dependent decrease of HRV occurs in MUO between the third and fifth decade of life. In MHO, HF significantly decreases around the age of 40 years. Cardiometabolic profile influences metabolic aging, altering the autonomic nervous system.
衰老与心率变异性（HRV）变化之间的关系可能取决于肥胖人群的代谢状况，即代谢健康肥胖（MHO）和代谢不健康肥胖（MUO）。我们旨在确定肥胖相关自主神经功能障碍变得显著的年龄，以及它是否根据代谢状况而有不同程度的降低。我们使用怀尔德曼代谢状况标准对99名成年人的HRV进行分析，并采用5分钟HRV评估自主神经系统。在MHO中，高频（HF）在40岁时开始下降。在MUO中，RR间期标准差（SDNN）、所有RR间期连续差值的均方根（RMSSD）、相邻间期差值超过50毫秒的数量占采集期所有间期的百分比（pNN50）、HF、低频（LF）、LF/HF（LF除以HF）和总功率（TP）在40岁时开始下降（部分共同方差为28%-36%）。总之，MUO在30至50岁之间会出现与年龄相关的HRV下降。在MHO中，HF在40岁左右显著下降。心脏代谢状况会影响代谢衰老，改变自主神经系统。
