Doherty T J, Valverde A, Valliant A E
Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
Can J Vet Res. 1988 Oct;52(4):481-3.
R51703, a substance with 5-hydroxytryptamine type 2 receptor antagonist properties, was studied to assess its potential as a sedative in cattle. Six cattle in the study group were given R51703 intramuscularly at a dose rate of 0.15 mg/kg. Sedation became obvious between 10 and 15 minutes postinjection in five of these animals and lasted for approximately 120 minutes. No significant changes (P less than or equal to 0.05) were observed in respiratory rate, arterial blood gas, acid-base values or systemic arterial blood pressure. Heart rate was significantly elevated at 40, 60, 90 and 120 minutes posttreatment, but dysrhythmias were not detected. Rumen motility, as judged by the contraction rate, was decreased but not to significant levels. All animals ate normally at the end of the study period. The results indicated that R51703 may have a role in the management of domestic cattle and that further work is indicated to assess its potential in this area.
R51703是一种具有5-羟色胺2型受体拮抗剂特性的物质，对其作为牛镇静剂的潜力进行了研究。研究组的六头牛以0.15毫克/千克的剂量率肌肉注射R51703。其中五头牛在注射后10至15分钟之间镇静作用变得明显，并持续约120分钟。呼吸频率、动脉血气、酸碱值或体循环动脉血压未观察到显著变化（P≤0.05）。治疗后40、60、90和120分钟心率显著升高，但未检测到心律失常。根据收缩率判断，瘤胃蠕动减弱，但未达到显著水平。在研究期结束时，所有动物均正常进食。结果表明，R51703可能在家畜管理中发挥作用，并且需要进一步开展工作以评估其在该领域的潜力。
