结节病作为一种自身免疫性疾病。
Sarcoidosis as an Autoimmune Disease.
机构信息
Laboratory of the Mosaic of Autoimmunity, St. Petersburg State University, St. Petersburg, Russia.
Phthisiopulmonology Department, St. Petersburg State Research Institute of Phthisiopulmonology, St. Petersburg, Russia.
出版信息
Front Immunol. 2020 Jan 8;10:2933. doi: 10.3389/fimmu.2019.02933. eCollection 2019.
Abstract
Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and "classic" autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.
摘要
尽管进行了大量的研究，但结节病的病因和发病机制仍不清楚。大多数研究人员暗示该病可能是自身免疫或免疫介导的。这篇综述试图对目前有关结节病自身免疫发病机制的信息进行综合分析，并分为以下四类：评估结节病患者和“经典”自身免疫性疾病中描述的临床体征、触发因素在结节病发展中的作用、疾病发展中免疫原性易感性的存在以及结节病中细胞和体液免疫反应的分析。研究结节病的病因和发病机制将改善诊断程序以及预后和患者的生活质量。
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Front Immunol. 2020 Jan 8;10:2933. doi: 10.3389/fimmu.2019.02933. eCollection 2019.
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