Morhenn V B, Smoller B R
California Skin Research Institute, San Diego, CA, USA.
J Cutan Med Surg. 1998 Jul;3(1):46-8. doi: 10.1177/120347549800300113.
Old scars rarely develop sarcoid lesions. To determine whether the immunophenotype of the cellular infiltrate found in sarcoid in scarred skin resembled that seen in sardoidosis, we performed routine staining with hematoxylin and eosin, as well as immunophenotyping of a sarcoid lesion in a scar. Currently, there is controversy about the etiology of sarcoidosis in general and about sarcoidal granulomas in scars in particular. A new hypothesis is suggested in this case report.
The purpose was to determine whether the cellular infiltrate in a sarcoidal granuloma in an old scar was similar to that in sarcoidosis.
Staining with hematoxylin and eosin as well as immunophenotyping was performed using standard techniques.
The dermis of the sarcoid lesion demonstrated predominantly macrophages, followed by CD-4+ T-helper cells. CD-8+ cytotoxic suppressor cells were rare.
The lymphoid cell infiltrate in a sarcoidal granuloma found in a scar is similar to that found in sarcoidosis. Furthermore, the staining pattern of sarcoid described in this paper and a review of the data in the literature suggest that sarcoidosis shares many characteristics of diseases with an autoimmune origin. Thus, we suggest that sarcoid isolated to scars represents a more benign variant of sarcoidosis, a possible systemic autoimmune disease.
陈旧性瘢痕很少发生结节病性病变。为了确定瘢痕皮肤中结节病病变处发现的细胞浸润的免疫表型是否与结节病中所见的相似，我们进行了苏木精和伊红常规染色以及瘢痕中结节病病变的免疫表型分析。目前，关于结节病的病因，尤其是瘢痕中的结节病性肉芽肿的病因存在争议。本病例报告提出了一个新的假说。
目的是确定陈旧瘢痕中结节病性肉芽肿的细胞浸润是否与结节病中的相似。
采用标准技术进行苏木精和伊红染色以及免疫表型分析。
结节病病变的真皮主要显示巨噬细胞，其次是CD-4 +辅助性T细胞。CD-8 +细胞毒性抑制细胞很少见。
瘢痕中发现的结节病性肉芽肿中的淋巴细胞浸润与结节病中的相似。此外，本文所述的结节病染色模式以及对文献数据的回顾表明，结节病具有许多自身免疫性起源疾病的特征。因此，我们认为局限于瘢痕的结节病代表结节病的一种更良性变体，一种可能的全身性自身免疫性疾病。
