Sharma Om P
Keck School of Medicine of USC, Los Angeles, California, USA.
Curr Opin Pulm Med. 2002 Sep;8(5):452-6. doi: 10.1097/00063198-200209000-00019.
The relation between sarcoidosis and autoimmune disorders was first suggested by Telium about half a century ago. He noted that there were certain clinical and laboratory similarities between systemic lupus erythematosus and sarcoidosis and mused that the common features were hyperglobulinemia, "hyalinosis" in the reticuloendothelial system, epithelioid cell granulomas, and periarterial hyaline zones in the spleen. Now, the inclusion of sarcoidosis into the group of disorders of autoimmunity is a discarded notion. Sarcoidosis does not meet the criteria for autoimmune disease. Nevertheless, there are ample examples of coexistence of sarcoidosis and a wider range of autoimmune disorders.
大约半个世纪前，特利姆首次提出结节病与自身免疫性疾病之间的关系。他指出，系统性红斑狼疮和结节病在某些临床和实验室特征上存在相似之处，并推测其共同特征为高球蛋白血症、网状内皮系统的“透明变性”、上皮样细胞肉芽肿以及脾脏的动脉周围透明带。如今，将结节病纳入自身免疫性疾病范畴的观点已被摒弃。结节病并不符合自身免疫性疾病的标准。然而，结节病与更广泛的自身免疫性疾病共存的例子却屡见不鲜。
