Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India.
Soft Matter. 2020 Feb 19;16(7):1779-1791. doi: 10.1039/c9sm02416f.
In this work, we report unusual niosomes (non-ionic surfactant based vesicles), prepared using non-ionic surfactant Tween 80 (T80) as well as Tween 20 (T20) and curcumin. Conventional niosomes consist of non-ionic surfactant and cholesterol. We found that, despite being a probiotic, curcumin plays a similar role to cholesterol in the formation and stabilization of niosomes. The prepared Tween-curcumin niosomes were characterised using Dynamic Light Scattering (DLS), zeta potential, Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), and Transmission Electron Microscopy (TEM) techniques. The curcumin-induced micelle to vesicle transition in the Tween surfactants was investigated by DLS, zeta potential, fluorescence anisotropy, and fluorescence lifetime studies. At room temperature (298 K), the prepared niosomes were found to be stable; however, at a higher temperature (333 K), the niosomes degrade gradually and irreversibly to form micelles. The temperature-dependent vesicle to micelle degradation was monitored using fluorescence anisotropy, absorption, DLS and Differential Scanning Calorimetry (DSC) measurements. Further, the Tween-curcumin niosomes show a controlled release of curcumin, which could open up the possibility of multidrug therapy.
在这项工作中，我们报告了不寻常的囊泡（基于非离子表面活性剂的囊泡），这些囊泡是使用非离子表面活性剂吐温 80（T80）以及吐温 20（T20）和姜黄素制备的。常规囊泡由非离子表面活性剂和胆固醇组成。我们发现，尽管姜黄素是一种益生菌，但它在囊泡的形成和稳定中起着类似于胆固醇的作用。使用动态光散射（DLS）、zeta 电位、扫描电子显微镜（SEM）、原子力显微镜（AFM）和透射电子显微镜（TEM）技术对制备的吐温-姜黄素囊泡进行了表征。通过 DLS、zeta 电位、荧光各向异性和荧光寿命研究，研究了姜黄素在吐温表面活性剂中诱导胶束向囊泡的转变。在室温（298 K）下，制备的囊泡被发现是稳定的；然而，在较高温度（333 K）下，囊泡逐渐不可逆地降解为胶束。使用荧光各向异性、吸收、DLS 和差示扫描量热法（DSC）测量监测温度依赖性的囊泡向胶束的降解。此外，吐温-姜黄素囊泡显示出姜黄素的控制释放，这可能为多药物治疗开辟了可能性。
