Facultad de Medicina Y Nutrición, Universidad Juárez del Estado de Durango, Durango, México.
Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Canoas 100, Col. Los Angeles 34067, Durango, Dgo, Mexico.
J Endocrinol Invest. 2020 Jul;43(7):995-1000. doi: 10.1007/s40618-020-01184-x. Epub 2020 Jan 22.
The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors.
Apparently healthy men and non-pregnant women aged 20-65 years were enrolled in a population-based cross-sectional study. Overweight, obesity, smoking, alcohol consumption, pregnancy, diagnosis of hypertension, diabetes, cardiovascular disease, liver disease, renal disease, malignancy, and medical treatment were exclusion criteria. Subjects were allocated into the MONW or normal-weight groups. MONW phenotype was defined by normal weight and the presence of at least one of the following cardiovascular risk factors: elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low HDL cholesterol.
A total of 542 subjects were enrolled and allocated into the MONW (n = 354) and normal-weight (n = 188) groups. The adjusted logistic regression analysis showed that the elevated TyG index is significantly associated with the presence of MONW phenotype (OR = 11.14; 95% CI 6.04-20.57), hyperglycemia (OR = 3.18; 95% CI 1.95-5.21), hypertriglyceridemia (OR = 399.19; 95% CI 94.01-1694.98), and low HDL-C (OR = 2.60; 95% CI 1.74-3.87), but not with elevated blood pressure (OR = 1.55; 95% CI 0.93-2.60).
Results of this study support that the TyG index may be a useful indicator to detect MONW phenotype and associated cardiovascular risk factors.
本研究旨在确定甘油三酯-葡萄糖（TyG）指数是否与代谢肥胖正常体重（MONW）表型及相关心血管危险因素有关。
本研究纳入了一项基于人群的横断面研究中的 20-65 岁的健康男性和非孕妇。排除标准为超重、肥胖、吸烟、饮酒、妊娠、高血压、糖尿病、心血管疾病、肝脏疾病、肾脏疾病、恶性肿瘤及正在接受治疗的患者。受试者被分为 MONW 或正常体重组。MONW 表型定义为体重正常且至少存在以下一种心血管危险因素：血压升高、血糖升高、甘油三酯升高和高密度脂蛋白胆固醇降低。
共纳入 542 名受试者，分为 MONW（n=354）和正常体重（n=188）组。调整后的逻辑回归分析显示，升高的 TyG 指数与 MONW 表型的存在显著相关（OR=11.14；95%CI 6.04-20.57），与血糖升高（OR=3.18；95%CI 1.95-5.21）、甘油三酯升高（OR=399.19；95%CI 94.01-1694.98）和低 HDL-C（OR=2.60；95%CI 1.74-3.87）相关，但与血压升高（OR=1.55；95%CI 0.93-2.60）无关。
本研究结果支持 TyG 指数可作为检测 MONW 表型及相关心血管危险因素的有用指标。
