Ramírez-Cruz Armando, Rios-Lugo María Judith, Soto-Sánchez Jacqueline, Juárez-Pérez Cuauhtémoc Arturo, Cabello-López Alejandro, Jiménez-Ramírez Carmina, Chang-Rueda Consuelo, Cruz Miguel, Hernández-Mendoza Héctor, Vazquez-Moreno Miguel
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, Mexico.
Posgrado en Biología Experimental, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Ciudad de México 09340, Mexico.
Metabolites. 2024 May 14;14(5):282. doi: 10.3390/metabo14050282.
Recently, the role of trace elements in the pathophysiology of obesity, insulin resistance (IR), and metabolic diseases has been explored. In this cross-sectional study, we aimed to assess the association of overweight, obesity, and cardiometabolic traits with serum copper (Cu) levels in 346 Mexican adults. Serum Cu level was measured by inductively coupled plasma mass spectrometry (ICP-MS). Anthropometrical data were collected, and biochemical parameters were measured. The triglyceride-glucose (TyG) index was used as a surrogate marker to evaluate IR. Overweight and obesity status was positively associated with the serum Cu level (β = 19.434 ± 7.309, = 0.008). Serum Cu level was observed to have a positive association with serum triglycerides level (β = 0.160 ± 0.045, < 0.001) and TyG (β = 0.001 ± 0.001, < 0.001). Additionally, high serum Cu level was positively associated with overweight and obesity status (odds ratio [OR] = 1.9, 95% confidence interval [95% CI] 1.1-3.4, = 0.014), hypertriglyceridemia (OR = 3.0, 95% CI 1.7-5.3, < 0.001), and IR (OR = 2.6, 95% CI 1.4-4.6, = 0.001). In conclusion, our results suggest that overweight, obesity, hypertriglyceridemia, and IR are positively associated with serum Cu levels in Mexican adults.
最近，微量元素在肥胖、胰岛素抵抗（IR）及代谢性疾病病理生理学中的作用已得到探索。在这项横断面研究中，我们旨在评估346名墨西哥成年人中超重、肥胖及心脏代谢特征与血清铜（Cu）水平之间的关联。血清铜水平通过电感耦合等离子体质谱法（ICP-MS）测定。收集人体测量数据并测量生化参数。甘油三酯-葡萄糖（TyG）指数用作评估IR的替代标志物。超重和肥胖状态与血清铜水平呈正相关（β = 19.434 ± 7.309，P = 0.008）。观察到血清铜水平与血清甘油三酯水平呈正相关（β = 0.160 ± 0.045，P < 0.001）以及与TyG呈正相关（β = 0.001 ± 0.001，P < 0.001）。此外，高血清铜水平与超重和肥胖状态（比值比[OR] = 1.9，95%置信区间[95%CI] 1.1 - 3.4，P = 0.014）、高甘油三酯血症（OR = 3.0，95%CI 1.7 - 5.3，P < 0.001）及IR（OR = 2.6，95%CI 1.4 - 4.6，P = 0.001）呈正相关。总之，我们的结果表明，超重、肥胖、高甘油三酯血症及IR与墨西哥成年人的血清铜水平呈正相关。
