Arenas J, Diaz V, Liras G, Gutierrez E, Santos I, Martinez A, Culebras J M
Servicios de Bioquímica y Neurología, Hospital 1 de Octubre, Madrid, Spain.
Clin Chem. 1988 Dec;34(12):2460-2.
We studied possible correlations between anatomopathological and clinical features and the values for total creatine kinase (CK; EC 2.7.3.2) and its isoenzymes, including the proportion of CK-MB, in a population displaying several neuromuscular pathologies. Although we observed no specific isoenzyme pattern associated with the different myopathies, we found isoenzyme analysis useful in studying the histopathological evolution of illness. We also considered whether the pathology was regenerative or nonregenerative, and what type of fiber (I or II) was involved. High CK-MB percentages (greater than 6%) were associated with regenerative and type I fiber myopathies, with regenerative type tissues being the principal factor associated with an increasing proportion of CK-MB. Studying the changes in CK-MB percentage in serum appears to be useful in discriminating neuromuscular from myocardial pathologies.
我们研究了在一群患有多种神经肌肉疾病的人群中，解剖病理学和临床特征与总肌酸激酶（CK；EC 2.7.3.2）及其同工酶的值之间的可能相关性，包括CK-MB的比例。尽管我们没有观察到与不同肌病相关的特定同工酶模式，但我们发现同工酶分析在研究疾病的组织病理学演变中很有用。我们还考虑了病理是再生性的还是非再生性的，以及涉及哪种类型的纤维（I型或II型）。高CK-MB百分比（大于6%）与再生性和I型纤维肌病相关，再生性组织是与CK-MB比例增加相关的主要因素。研究血清中CK-MB百分比的变化似乎有助于区分神经肌肉疾病和心肌疾病。
