Wolf P L, Griffiths J C, Erickson R
Enzyme. 1978;23(6):413-5. doi: 10.1159/000458611.
Increase in size of bone is characteristic of acromegaly. In addition, hypertrophy of other tissues including skeletal muscle and associated myopathy may occur. We recently found 10 U/1 of isoenzyme creatine kinase 2 (MB) or 10.9% of total creatine kinase in a patient with acromegaly who did not show clinical or laboratory evidence of acute myocardial necrosis. The myopathy associated with acromegaly is thus another cause for the presence of serum CK 2 (MB), and CK 2 (MB) is not a specific isoenzyme for myocardial damage since it may be identified in the serum of patients with skeletal muscle conditions.
骨骼增大是肢端肥大症的特征。此外，其他组织包括骨骼肌的肥大及相关的肌病也可能发生。我们最近在一名肢端肥大症患者中发现其肌酸激酶同工酶2（MB）为10 U/1，或占总肌酸激酶的10.9%，而该患者并无急性心肌坏死的临床或实验室证据。因此，与肢端肥大症相关的肌病是血清肌酸激酶2（MB）存在的另一个原因，并且肌酸激酶2（MB）并非心肌损伤的特异性同工酶，因为在患有骨骼肌疾病的患者血清中也可检测到。
