脂肪、肥胖与内皮细胞
Fat, Obesity, and the Endothelium.
作者信息
Yucel Nora, Arany Zolt
机构信息
Perelman School of Medicine, University of Pennsylvania.
出版信息
Curr Opin Physiol. 2019 Dec;12:44-50. doi: 10.1016/j.cophys.2019.09.003. Epub 2019 Sep 19.
Abstract
Endothelial cells line all blood vessels in vertebrates. These cells contribute to whole-body nutrient distribution in a variety of ways, including regulation of local blood flow, regulation of trans-endothelial nutrient transport, and paracrine effects. Obesity elicits dramatic whole-body nutrient redistribution, in particular of fat. We briefly review here recent progress on understanding endothelial fat transport; the impact of obesity on the endothelium; and, conversely, how endothelial function can modulate obesity.
摘要
内皮细胞排列在脊椎动物的所有血管内壁。这些细胞通过多种方式促进全身营养物质的分布，包括调节局部血流、调节跨内皮营养物质运输以及旁分泌作用。肥胖会引发显著的全身营养物质重新分配，尤其是脂肪的重新分配。我们在此简要回顾一下近期在理解内皮细胞脂肪运输、肥胖对内皮细胞的影响以及相反地内皮细胞功能如何调节肥胖方面所取得的进展。
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