Gandy G, Jacobson W
Arch Dis Child. 1977 Jan;52(1):1-6. doi: 10.1136/adc.52.1.1.
The birthweights of 100 infants with erythroblastosis were carefully matched as to sex, gestational age, and parity with the birthweights of 200 control infants born during the same period. At all gestational ages the average birthweight of the affected infants was below that of the controls, the average reduction being 227 g. The more severely affected infants tended to be at a lower centile for birthweight than were the mildly affected ones. The relationships between maternal serum folate, cord blood serum folate, and centile for birthweight among affected infants were also studied. There was a strong correlation between low maternal serum folate and the incidence of small-for-dates babies among the affected infants. There was also a strong correlation between maternal and cord blood serum folate values. There was a lack of correlation between maternal serum folate and cord blood haemoglobin. It is concluded that infants with erythroblastosis are lighter than controls and that the reason for this may be a shortage of folic acid available for fetal growth.
100例患有新生儿溶血病的婴儿的出生体重，在性别、孕周和产次方面与同期出生的200例对照婴儿的出生体重进行了仔细匹配。在所有孕周，患病婴儿的平均出生体重均低于对照组，平均降低227克。病情较重的婴儿出生体重百分位数往往低于病情较轻的婴儿。还研究了患病婴儿的母亲血清叶酸、脐血血清叶酸与出生体重百分位数之间的关系。母亲血清叶酸水平低与患病婴儿中小于胎龄儿的发生率之间存在很强的相关性。母亲和脐血血清叶酸值之间也存在很强的相关性。母亲血清叶酸与脐血血红蛋白之间缺乏相关性。得出的结论是，患有新生儿溶血病的婴儿比对照组婴儿轻，其原因可能是胎儿生长可用的叶酸短缺。
