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叶酸对母儿血型不合婴儿出生体重及生长的影响。III. 补充叶酸的效果。

Influence of folic acid on birthweight and growth of the erythroblastotic infant. III. Effect of folic acid supplementation.

作者信息

Gandy G, Jacobson W

出版信息

Arch Dis Child. 1977 Jan;52(1):16-21. doi: 10.1136/adc.52.1.16.

Abstract

Seventeen infants with severe (14) or moderately severe (3) erythroblastosis were given daily oral supplements of 2-5 or 5 mg folic acid from day 16 (average) to 3-2 months (average). Their rate of weight gain, expressed as weight centiles, was followed for 1 year and was compared with that of a very similar group of 34 erythroblastotic infants without folic acid supplements. By the end of the 4th month, just after stopping additional folate intake, the median centiles for weight had risen from the 40th to the 80th centile, while in the untreated control group they rose during this period from the 35th to the 50th centile. During the second half of the year both groups declined in weight centiles, the 'treated' group ending up at the 50th centile for weight, while the control group fell to the 25th.

摘要

17名患有重度(14名)或中度重度(3名)胎儿成红细胞增多症的婴儿,从第16天(平均)至3 - 2个月(平均)每天口服2 - 5毫克或5毫克叶酸。以体重百分位数表示的体重增加率被跟踪了1年,并与34名未补充叶酸的非常相似的胎儿成红细胞增多症婴儿组进行了比较。在第4个月末,刚停止额外叶酸摄入后,体重的中位数百分位数从第40百分位数升至第80百分位数,而在未治疗的对照组中,在此期间从第35百分位数升至第50百分位数。在下半年,两组的体重百分位数均下降,“治疗”组最终体重处于第50百分位数,而对照组降至第25百分位数。

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Folic acid levels in erythroblastotic infants.患新生儿溶血病婴儿的叶酸水平
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本文引用的文献

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Folic acid in low birthweight infants.低出生体重儿中的叶酸
Arch Dis Child. 1974 Sep;49(9):736-8. doi: 10.1136/adc.49.9.736.
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Iron, vitamin E, and folate in the preterm infant.早产儿体内的铁、维生素E和叶酸
J Pediatr. 1974 Dec;85(6):742-52. doi: 10.1016/s0022-3476(74)80334-3.
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A follow-up study of survivors of Rh-haemolytic disease.一项关于Rh溶血病幸存者的随访研究。
Dev Med Child Neurol. 1974 Oct;16(5):592-611. doi: 10.1111/j.1469-8749.1974.tb04178.x.

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