Gandy G, Jacobson W
Arch Dis Child. 1977 Jan;52(1):16-21. doi: 10.1136/adc.52.1.16.
Seventeen infants with severe (14) or moderately severe (3) erythroblastosis were given daily oral supplements of 2-5 or 5 mg folic acid from day 16 (average) to 3-2 months (average). Their rate of weight gain, expressed as weight centiles, was followed for 1 year and was compared with that of a very similar group of 34 erythroblastotic infants without folic acid supplements. By the end of the 4th month, just after stopping additional folate intake, the median centiles for weight had risen from the 40th to the 80th centile, while in the untreated control group they rose during this period from the 35th to the 50th centile. During the second half of the year both groups declined in weight centiles, the 'treated' group ending up at the 50th centile for weight, while the control group fell to the 25th.
17名患有重度（14名）或中度重度（3名）胎儿成红细胞增多症的婴儿，从第16天（平均）至3 - 2个月（平均）每天口服2 - 5毫克或5毫克叶酸。以体重百分位数表示的体重增加率被跟踪了1年，并与34名未补充叶酸的非常相似的胎儿成红细胞增多症婴儿组进行了比较。在第4个月末，刚停止额外叶酸摄入后，体重的中位数百分位数从第40百分位数升至第80百分位数，而在未治疗的对照组中，在此期间从第35百分位数升至第50百分位数。在下半年，两组的体重百分位数均下降，“治疗”组最终体重处于第50百分位数，而对照组降至第25百分位数。
