Lütjen-Drecoll E, Tamm E
Department of Anatomy, University of Erlangen-Nürnberg, West Germany.
Exp Eye Res. 1988 Nov;47(5):761-9. doi: 10.1016/0014-4835(88)90043-7.
Topically applied prostaglandin F2 alpha has been shown to lower intraocular pressure in cynomolgus monkeys. In this study the morphological changes, following topical treatment with 4-50 micrograms of prostaglandin F2 alpha for 4-8 days, were investigated. Semiquantitation of (1) accumulation of white blood cells as one sign of inflammation, (2) edema and (3) enlarged spaces between ciliary muscle cells were performed. Eighty sections per eye encompassing the whole circumference were investigated. No accumulation of white blood cells was seen in any of the eyes. Slight edema in the most anterior part of the ciliary processes occurred in most eyes, but only in part of the circumference. These changes could be either directly induced by the prostaglandin treatment or secondary to the decrease in intraocular pressure. The most pronounced change was the dilatation of the intramuscular spaces. These enlarged spaces could explain the physiologically shown increase in uveoscleral outflow.
局部应用前列腺素F2α已被证明可降低食蟹猴的眼压。在本研究中，研究了用4 - 50微克前列腺素F2α局部治疗4 - 8天后的形态学变化。对以下方面进行了半定量分析：（1）作为炎症迹象之一的白细胞积聚；（2）水肿；（3）睫状肌细胞间间隙增大。对每只眼睛环绕整个圆周的80个切片进行了研究。在任何一只眼睛中均未观察到白细胞积聚。大多数眼睛的睫状体最前部出现轻微水肿，但仅在部分圆周处。这些变化可能是由前列腺素治疗直接引起的，也可能是眼压降低的继发结果。最明显的变化是肌内间隙扩张。这些扩大的间隙可以解释生理学上显示的葡萄膜巩膜流出增加。
