Hernandez T D, Schallert T
Department of Psychology, University of Texas, Austin 78712.
Exp Neurol. 1988 Dec;102(3):318-24. doi: 10.1016/0014-4886(88)90226-9.
The effects of the gamma-aminobutyric acid antagonist, pentylenetetrazol (PTZ), on recovery from somatosensory and motor asymmetries after unilateral sensorimotor cortex lesions were investigated. Behavior was assessed using a bilateral tactile stimulation test and a measure of forelimb motor coordination. Immediately after surgery, the PTZ-treated and saline (SAL) control groups both exhibited severe ipsilateral behavioral asymmetries. Rats receiving PTZ recovered significantly faster from somatosensory asymmetry than those receiving SAL. Recovery was complete in the PTZ group within 3 postoperative weeks, while the SAL group failed to reach a comparable level until 2 months after surgery. There was no difference between PTZ and SAL groups on recovery of forelimb motor coordination. No difference in lesion size between the SAL and the PTZ groups could be found. These data are consistent with the hypothesis that post-traumatic neuronal depression may contribute to the severity of sensorimotor deficits observed after brain damage.
研究了γ-氨基丁酸拮抗剂戊四氮（PTZ）对单侧感觉运动皮层损伤后体感和运动不对称恢复的影响。使用双侧触觉刺激试验和前肢运动协调性测量来评估行为。术后立即，PTZ治疗组和生理盐水（SAL）对照组均表现出严重的同侧行为不对称。接受PTZ的大鼠比接受SAL的大鼠从体感不对称中恢复得明显更快。PTZ组在术后3周内恢复完全，而SAL组直到术后2个月才达到可比水平。PTZ组和SAL组在前肢运动协调性恢复方面没有差异。SAL组和PTZ组之间的损伤大小没有差异。这些数据与创伤后神经元抑制可能导致脑损伤后观察到的感觉运动缺陷严重程度的假设一致。
