miRNAs 和 lncRNAs 在包虫病中的作用。
miRNAs and lncRNAs in and Echinococcosis.
机构信息
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
出版信息
Int J Mol Sci. 2020 Jan 22;21(3):730. doi: 10.3390/ijms21030730.
Echinococcosis are considered to be potentially lethal zoonotic diseases that cause serious damage to hosts. The metacestode of and can result in causing the alveolar and cystic echinococcoses, respectively. Recent studies have shown that non-coding RNAs are widely expressed in spp. and hosts. In this review, the two main types of non-coding RNAs-long non-coding RNAs (lncRNAs) and microRNAs (miRNAs)-and the wide-scale involvement of these molecules in these parasites and their hosts were discussed. The expression pattern of miRNAs in spp. is species- and developmental stage-specific. Furthermore, common miRNAs were detected in three spp. and their intermediate hosts. Here, we primarily focus on recent insights from transcriptome studies, the expression patterns of miRNAs and lncRNAs, and miRNA-related databases and techniques that are used to investigate miRNAs in and echinococcosis. This review provides new avenues for screening therapeutic and diagnostic markers.
包虫病被认为是具有潜在致命性的人畜共患疾病，会对宿主造成严重损害。细粒棘球蚴和多房棘球蚴的囊尾蚴分别可导致泡型和囊型包虫病。最近的研究表明，非编码 RNA 在 spp. 和宿主中广泛表达。在这篇综述中，讨论了两种主要类型的非编码 RNA——长非编码 RNA（lncRNA）和 microRNAs（miRNAs）——以及这些分子在这些寄生虫及其宿主中的广泛参与。miRNAs 在 spp. 中的表达模式具有物种和发育阶段特异性。此外，在三种 spp. 及其中间宿主中检测到了常见的 miRNAs。在这里，我们主要关注转录组研究、miRNAs 和 lncRNAs 的表达模式以及 miRNA 相关数据库和技术的最新研究进展，这些技术用于研究 和包虫病中的 miRNAs。本综述为筛选治疗和诊断标志物提供了新的途径。
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