Zhang Wenbao, McManus Donald P
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
FEMS Immunol Med Microbiol. 2006 Jun;47(1):24-41. doi: 10.1111/j.1574-695X.2006.00060.x.
Echinococcosis is a cosmopolitan zoonosis caused by adult or larval stages of cestodes belonging to the genus Echinococcus (family Taeniidae). The two major species of medical and public health importance are Echinococcus granulosus and Echinococcus multilocularis, which cause cystic echinococcosis and alveolar echinococcosis, respectively. Both cystic echinococcosis and alveolar echinococcosis are serious diseases, the latter especially so, with a high fatality rate and poor prognosis if managed inappropriately. This review highlights recent advances in immunity to infection and vaccination against both parasites in their intermediate and definitive hosts and procedures for diagnosis of cystic echinococcosis and alveolar echinococcosis, including the value of immunodiagnostic and DNA approaches. There is discussion also of progress in genomics and related technologies that is providing valuable insights on the functional biology of the Echinococcus organisms. These studies will underpin future research that will reveal a better understanding of the Echinococcus-host interplay, and suggest new avenues for the identification of additional targets for diagnosis, vaccination and chemotherapy.
棘球蚴病是一种世界性人畜共患病，由棘球绦虫属（带科）的成虫或幼虫阶段引起。具有医学和公共卫生重要性的两个主要物种是细粒棘球绦虫和多房棘球绦虫，分别引起囊型棘球蚴病和泡型棘球蚴病。囊型棘球蚴病和泡型棘球蚴病都是严重疾病，后者尤其如此，如果处理不当，死亡率高且预后不良。本综述重点介绍了中间宿主和终末宿主对这两种寄生虫感染的免疫和疫苗接种方面的最新进展，以及囊型棘球蚴病和泡型棘球蚴病的诊断程序，包括免疫诊断和DNA方法的价值。还讨论了基因组学及相关技术的进展，这些进展为棘球绦虫生物体的功能生物学提供了有价值的见解。这些研究将为未来的研究奠定基础，从而更好地理解棘球绦虫与宿主的相互作用，并为识别诊断、疫苗接种和化疗的其他靶点提供新途径。
