Post Graduate Program in Health Sciences, São Francisco University, Bragança Paulista, SP CEP 129160-400, Brazil.
Snyder Institute of Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Int J Mol Sci. 2020 Jan 23;21(3):760. doi: 10.3390/ijms21030760.
Chrysin exhibits anti-inflammatory and antioxidant activities. Here, the gastroprotective effect of chrysin was investigated in mouse models of gastric ulcer induced by absolute ethanol, acetic acid, and ischemia-reperfusion injury. The gastric-healing effect was evaluated at 7 and 14 days after treatment; the mechanism of action was verified using the expression of metalloproteinase 2 () and 9 (), caspase-3, cyclooxygenase 1 () and 2 (), epidermal growth factor (), and interleukin-10. Chrysin (10 mg/kg) inhibited macroscopic lesions and increased catalase activity in the mouse model established using absolute ethanol. It ameliorated the gastric ulcer caused by acetic acid by improving the expression of inflammatory genes such as , inhibiting negative remodeling promoted by MMP-9, increasing cell proliferation effect via , and reducing cellular apoptosis by modulating caspase-3. A faster healing effect was evident in the first 7 days of treatment compared to 14 days of treatment, indicating the pharmacological potential of chrysin. Overall, these results demonstrate the potent effect of chrysin in the gastrointestinal tract and elucidate the genes involved in the healing of gastric ulcers. Moreover, an increase in the levels of gastric mucosa defensive factors is involved in the activity of chrysin in the gastric mucosa.
白杨素具有抗炎和抗氧化活性。在这里，研究了白杨素在乙醇、乙酸和缺血再灌注损伤诱导的胃溃疡小鼠模型中的胃保护作用。在治疗后 7 天和 14 天评估胃愈合效果；通过表达金属蛋白酶 2()和 9()、半胱氨酸天冬氨酸蛋白酶 3、环氧化酶 1()和 2()、表皮生长因子和白细胞介素 10 来验证作用机制。白杨素（10mg/kg）抑制了使用乙醇建立的小鼠模型中的宏观病变并增加了过氧化氢酶活性。它通过改善炎症基因如的表达，抑制 MMP-9 促进的负重塑，通过增加细胞增殖作用，以及通过调节半胱氨酸天冬氨酸蛋白酶 3来减少细胞凋亡，从而改善了由乙酸引起的胃溃疡。与 14 天治疗相比，在治疗的前 7 天，更快的愈合效果明显，表明白杨素具有药理学潜力。总的来说，这些结果表明白杨素在胃肠道中具有强大的作用，并阐明了参与胃溃疡愈合的基因。此外，胃黏膜防御因子水平的增加参与了白杨素在胃黏膜中的活性。
