Phyllanthacidoid U: a new -glycosyl norbisabolane sesquiterpene from (L.) skeels.

A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester -glycosyl found mostly in the titled plant growing in Thailand, compound possessed a rare --glucosamine-2--acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in was ()-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or -hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene displayed stronger anti hepatitis B virus (HBV) activity with IC values of 1.69 ± 0.22 and 2.79 ± 0.69 μM towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.