Dusbábek F, Skárková-Spaková V, Vítovec J, Stĕrba J
South Bohemian Biological Centre, Czechoslovak Academy of Sciences, Ceské Budĕjovice.
Folia Parasitol (Praha). 1988;35(3):259-68.
Dynamics of granular leucocyte response in peripheral blood of naive and sensitized pigeons infested with Argas polonicus larvae was only slightly dissimilar. In both cases a marked increase of heterophil and eosinophil counts and only a mild increase of basophil count were recorded at 6 hours post-infestation. In naive hosts the basophil count increased again at 96 hours post-infestation, but in sensitized hosts it did so as early as 48 hours post-tick attachment and was also accompanied by an increase of eosinophil levels 72 and 96 hours post-infestation. Cutaneous response of sensitized hosts at the tick feeding site was characterized by a large heterophil accumulation at 24 hours post-infestation, by an increased eosinophil count at 48 hours and basophil counts at 72 and 96 hours post-infestation. In primary hosts lesions were characterized by a mild increase of heterophil count later than 48 hours post-infestation and by slight eosinophil accumulations at 24 and 48 hours post-tick attachment, as well as basophil accumulation as late as 96 hours post-infestation. Cutaneous lesions of sensitized hosts were accompanied by apparent inflammatory changes which were mild and sometimes missing in primary hosts. Cytotoxic and degenerative alterations of basophils and other granulocytes were observed as well as vesiculation of secretory granules of basophils. Cutaneous response of sensitized hosts to larval A. polonicus feeding can be characterized as a cutaneous basophil hypersensitivity.
未感染过的和已致敏的家鸽外周血中粒细胞对波兰钝缘蜱幼虫侵袭的反应动态仅有轻微差异。在这两种情况下，感染后6小时均记录到嗜异性粒细胞和嗜酸性粒细胞计数显著增加，而嗜碱性粒细胞计数仅轻度增加。在未感染过的宿主中，感染后96小时嗜碱性粒细胞计数再次增加，但在已致敏的宿主中，早在蜱附着后48小时就出现了这种情况，并且在感染后72小时和96小时还伴随着嗜酸性粒细胞水平的增加。已致敏宿主在蜱叮咬部位的皮肤反应特点是，感染后24小时有大量嗜异性粒细胞积聚，48小时嗜酸性粒细胞计数增加，72小时和96小时嗜碱性粒细胞计数增加。在初次宿主中，损伤的特点是感染后48小时后嗜异性粒细胞计数轻度增加，蜱附着后24小时和48小时有轻微嗜酸性粒细胞积聚，以及直到感染后96小时才有嗜碱性粒细胞积聚。已致敏宿主的皮肤损伤伴有明显的炎症变化，而初次宿主的炎症变化轻微，有时甚至没有。观察到嗜碱性粒细胞和其他粒细胞的细胞毒性和退行性改变以及嗜碱性粒细胞分泌颗粒的空泡化。已致敏宿主对波兰钝缘蜱幼虫取食的皮肤反应可被描述为皮肤嗜碱性粒细胞超敏反应。
