Hospital Clínico Universitario, INCLIVA, Nephrology department, Valencia , España.
Unidad Avanzada de Investigación y Diagnóstico Ecográfico y Renal, Clínica Puerto Ordaz, Venezuela.
Clin Investig Arterioscler. 2020 May-Jun;32(3):129-134. doi: 10.1016/j.arteri.2019.10.006. Epub 2020 Jan 21.
Chronic kidney disease represents a true inflammatory state, and is related to multiple cardiovascular risk factors. Coronary artery disease is the major complication, and has usually been associated with non-classical or uraemic related factors that include the disturbance of calcium and phosphorus metabolism, among others. Recent clinical evidence shows that specific body fat deposition like epicardial adipose tissue is an additional factor to consider when evaluating cardiovascular risk in the general population and kidney patients. Direct interaction of this tissue and coronary vessels with consequent mediation of pro-atherogenic substances have a local process ending in endothelial damage. Although the population of renal patients has been poorly evaluated, future studies should determine precisely whether an increase in epicardial fat is truly associated with cardiovascular morbidity and mortality in this risk group.
慢性肾脏病是一种真正的炎症状态，与多种心血管危险因素有关。冠状动脉疾病是主要的并发症，通常与非经典或尿毒症相关的因素有关，包括钙和磷代谢紊乱等。最近的临床证据表明，在评估普通人群和肾脏病患者的心血管风险时，特定的身体脂肪沉积，如心外膜脂肪组织，是一个需要考虑的额外因素。这种组织与冠状动脉的直接相互作用以及随后促动脉粥样物质的介导作用，导致内皮损伤，形成一个局部过程。尽管肾脏病患者的人群评估不足，但未来的研究应该确定在心外膜脂肪增加是否真的与该风险组的心血管发病率和死亡率相关。
