Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 106, Taiwan.
Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 413, Taiwan.
Sci Rep. 2020 Jan 24;10(1):1155. doi: 10.1038/s41598-020-58184-3.
The preparation of chitosan-tripolyphosphate (chitosan-TPP) particles by the spray drying had been reported word widely for a sustained release of drugs to prevent rapid drug metabolism. Although the spray drying is a straightforward procedure turning a liquid feed into a well-defined dry powder, seldom research works were focusing on how the processing parameters and liquid feeding constitutions of spray drying system might affect the properties of spray-dried chitosan particles loaded with drugs, such as the particle size and morphologies, which would be very important to drug encapsulation and dissolution of the drug delivery design. This study thus prepared the chitosan particles with theophylline (TH) loaded as a model drug and TPP as cross-linker at various spray drying conditions. Our results indicate the diameter of the TH/chitosan-TPP particles made by customized spray drying apparatus spans from 424 to 497 nm with a geometric standard deviation of less than 2. The corresponding release of TH was tunable by the chitosan-TPP matrix density under the selected spray drying temperature and the carrying air flow rate. These results suggest an indeed need for optimized spray drying processing conditions to make the ideal spray-dried TH/chitosan-TPP particles for the desired drug delivery.
壳聚糖-三聚磷酸钠（chitosan-TPP）颗粒通过喷雾干燥法制备已被广泛报道，这种方法可以使药物持续释放，以防止药物迅速代谢。虽然喷雾干燥是一种将液体进料转化为明确定义的干粉的简单过程，但很少有研究工作关注喷雾干燥系统的加工参数和液体进料组成如何影响载药喷雾干燥壳聚糖颗粒的性质，例如粒径和形态，这对于药物包封和药物传递设计中的药物溶解非常重要。因此，本研究在各种喷雾干燥条件下，以茶碱（TH）为模型药物，以三聚磷酸钠（TPP）为交联剂，制备了壳聚糖颗粒。结果表明，用定制喷雾干燥装置制备的 TH/壳聚糖-TPP 颗粒的直径为 424nm 至 497nm，几何标准偏差小于 2。在选定的喷雾干燥温度和载气流速下，TH 的释放可以通过壳聚糖-TPP 基质密度进行调节。这些结果表明，确实需要优化喷雾干燥工艺条件，以制备理想的载药喷雾干燥 TH/壳聚糖-TPP 颗粒用于所需的药物传递。
