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基于 PLGA 的可生物降解微球在药物传递中的应用：研究与应用的新进展。

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application.

机构信息

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.

Hunan Zaochen Nanorobot Co., Ltd, Liuyang, China.

出版信息

Drug Deliv. 2021 Dec;28(1):1397-1418. doi: 10.1080/10717544.2021.1938756.

DOI:10.1080/10717544.2021.1938756
PMID:34184949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8248937/
Abstract

Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocular-related diseases.

摘要

可生物降解微球由于能够通过多种途径递送各种性质的药物分子，并且具有低剂量和低副作用的优点，因此在医学领域得到了广泛的应用。聚（乳酸-共-羟基乙酸）共聚物（PLGA）是目前应用最广泛的可生物降解材料之一，具有良好的生物相容性。在应用中，可以根据药物分子的性质和药物释放速率的要求选择具有特定单体比例（乳酸和羟基乙酸）的 PLGA。基于 PLGA 的可生物降解微球已在药物递送领域进行了研究，包括各种抗癌药物、蛋白质或肽类药物、细菌或病毒 DNA 等的递送。本文综述了 PLGA 可生物降解微球的基本知识和现状，并讨论了 PLGA 聚合物材料的选择。然后，介绍了 PLGA 微球的制备方法，包括乳化、微流控技术、电喷雾和喷雾干燥。最后，本文总结了 PLGA 微球在药物递送和治疗肺部及眼部相关疾病中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe49/8248937/648ecbd95cb6/IDRD_A_1938756_F0010_B.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe49/8248937/5715bb80f493/IDRD_A_1938756_F0006_C.jpg
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