Masters in Biomedical Science Program, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
Arizona College of Osteopathic Medicine, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
FEMS Yeast Res. 2020 Feb 1;20(1). doi: 10.1093/femsyr/foaa005.
Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulence of C. albicans, and this transition is regulated in response to a range of environmental cues that are encountered in distinct host niches. Many unique transcription factors contribute to the transcriptional regulatory network that integrates these distinct environmental cues and determines which phenotypic state will be expressed. These hyphal morphogenesis regulators have been extensively investigated, and represent an increasingly important focus of study, due to their central role in controlling a key C. albicans virulence attribute. This review provides a succinct summary of the transcriptional regulatory factors and environmental signals that control hyphal morphogenesis in C. albicans.
白色念珠菌是一种多态共生体生物，也是人类机会性真菌病原体。单细胞出芽酵母和多细胞丝状菌丝生长形态之间的形态转换在白色念珠菌的毒力中起着至关重要的作用，这种转换是响应在不同宿主小生境中遇到的一系列环境线索进行调节的。许多独特的转录因子有助于转录调控网络，该网络整合了这些不同的环境线索，并决定将表达哪种表型状态。由于其在控制白色念珠菌关键毒力属性中的核心作用，这些菌丝形态发生调节剂已得到广泛研究，并且日益成为研究的重点。本文简要总结了控制白色念珠菌菌丝形态发生的转录调控因子和环境信号。
