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Finding the needle in a haystack: Mapping antifungal drug resistance in fungal pathogen by genomic approaches.

作者信息

Sanglard Dominique

机构信息

Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

出版信息

PLoS Pathog. 2019 Jan 31;15(1):e1007478. doi: 10.1371/journal.ppat.1007478. eCollection 2019 Jan.

DOI:10.1371/journal.ppat.1007478
PMID:30703166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6355021/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b247/6355021/51095977c1d9/ppat.1007478.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b247/6355021/51095977c1d9/ppat.1007478.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b247/6355021/51095977c1d9/ppat.1007478.g001.jpg

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Evolution of drug resistance in an antifungal-naive chronic infection.抗真菌药物初治慢性感染中耐药性的演变。
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12040-12045. doi: 10.1073/pnas.1807698115. Epub 2018 Nov 2.
2
MARDy: Mycology Antifungal Resistance Database.MARDy：真菌抗药性数据库。
Bioinformatics. 2018 Sep 15;34(18):3233-3234. doi: 10.1093/bioinformatics/bty321.
3
Gene flow contributes to diversification of the major fungal pathogen Candida albicans.基因流促进了主要真菌病原体白念珠菌的多样化。
利用基因组学理解真菌病原体毒力和耐药性的机制。
Biochem Soc Trans. 2022 Jun 30;50(3):1259-1268. doi: 10.1042/BST20211123.
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Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance.全基因组分析实验进化的假丝酵母菌揭示了多种新型多药耐药机制。
mBio. 2021 Apr 5;12(2):e03333-20. doi: 10.1128/mBio.03333-20.
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