Robertson G S, MacGregor D M, Jones C J
Br J Anaesth. 1977 Feb;49(2):133-40. doi: 10.1093/bja/49.2.133.
In a double-blind study of 100 outpatients receiving methohexitone, nitrous oxide and halothane, the administration of doxapram 80 mg i.v. was associated with a significantly more rapid recovery from anaesthesia, the effect being more obvious in women than men. Doxapram produced a reduction of 3-4 min in the time of recovery to a safe level of consciousness. The effect was probably a result of the more rapid elimination of halothane caused by stimulation of respiration. In the patients who received doxapram the incidence of minor complications during recovery was reduced and there was some evidence of an improvement in the quality of recovery.
在一项针对100名接受美索比妥、氧化亚氮和氟烷的门诊患者的双盲研究中，静脉注射80毫克多沙普仑与麻醉后恢复明显加快有关，女性的效果比男性更明显。多沙普仑使恢复到安全意识水平的时间缩短了3 - 4分钟。这种效果可能是由于呼吸刺激导致氟烷消除更快的结果。接受多沙普仑的患者恢复期间轻微并发症的发生率降低，并且有一些证据表明恢复质量有所改善。
