Women's Health Institute, Cleveland Clinic, Cleveland, OH; Center for Bioethics, Cleveland Clinic, Cleveland, OH.
Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.
Am J Obstet Gynecol. 2020 Jun;222(6):584.e1-584.e5. doi: 10.1016/j.ajog.2020.01.032. Epub 2020 Jan 22.
While uterus transplantation was once considered only a theoretical possibility for patients with uterine factor infertility, researchers have now developed methods of transplantation that have led to successful pregnancies with multiple children born to date. Because of the unique and significant nature of this type of research, it has been undertaken with collaboration not only with scientists and physicians but also with bioethicists, who paved the initial path for research of uterus transplantation to take place. As the science of uterus transplantation continues to advance, so too must the public dialogue among obstetrician/gynecologists, transplant surgeons, bioethicists, and other key stakeholders in defining the continued direction of research in addition to planning for the clinical implementation of uterus transplantation as a therapeutic option. Given the rapid advances in this field, the time has come to revisit the fundamental questions raised at the inception of uterus transplantation and, looking forward, determine the future of this approach given emerging data on the procedure's impact on individuals, families, and society.
虽然子宫移植曾经被认为只是子宫因素不孕患者的一种理论可能性，但研究人员现在已经开发出了移植方法，这些方法已经导致了多次成功怀孕，并诞生了多个孩子。由于这种类型的研究具有独特而重要的性质，因此不仅与科学家和医生合作，而且还与生物伦理学家合作，为子宫移植研究的开展铺平了道路。随着子宫移植科学的不断进步，妇产科医生、移植外科医生、生物伦理学家和其他关键利益相关者之间的公众对话也必须跟上，除了规划子宫移植作为一种治疗选择的临床实施之外，还要为研究的持续方向进行定义。鉴于该领域的快速发展，现在是时候重新审视子宫移植开始时提出的基本问题，并展望一下，鉴于该手术对个人、家庭和社会的影响的新数据，确定该方法的未来。
