Laboratorio de Carcinogénesis y Toxicología, Unidad de Biomedicina, Facultad de Estudios Superiores, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, Tlalnepantla, CP 54059, Estado de México, Mexico; Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico.
Laboratorio de Carcinogénesis y Toxicología, Unidad de Biomedicina, Facultad de Estudios Superiores, Universidad Nacional Autónoma de México, Av. De los Barrios 1, Col. Los Reyes Iztacala, Tlalnepantla, CP 54059, Estado de México, Mexico.
Toxicol Lett. 2020 Apr 1;322:111-119. doi: 10.1016/j.toxlet.2020.01.016. Epub 2020 Jan 22.
The increasing concern of possible adverse effects on human health derived from occupational engineered nanomaterials (ENMs) exposure is an issue addressed by entities related to provide guidelines and/or protocols for ENMs regulation. Here we analysed 17 entities from America, Europe and Asia, and some of these entities provide limits of exposure extrapolated from the non-nanosized counterparts of ENMs. The international landscape shows that recommendations are mostly made for metal oxide based ENMs and tonnage is one of the main criteria for ENMs registration, however, sub-nanometric ENMs are emerging and perhaps a novel category of ENMs will appear soon. We identify that besides the lack of epidemiological evidence of ENMs toxicity in humans and difficulties in analysing the toxicological data derived from experimental models, the lack of information on airborne concentrations of ENMs in occupational settings is an important limitation to improve the experimental designs. The development of regulations related to ENMs exposure would lead to provide safer work places for ENMs production without delaying the nanotechnology progress but will also help to protect the environment by taking opportune and correct measures for nanowaste, considering that this could be a great environmental problem in the coming future.
人们越来越担心职业性工程纳米材料 (ENMs) 暴露可能对人类健康产生不良影响，这是与提供 ENMs 监管指南和/或协议相关的实体所关注的问题。在这里，我们分析了来自美洲、欧洲和亚洲的 17 个实体，其中一些实体提供了从 ENMs 的非纳米级对应物推断出的暴露限值。国际形势表明，建议主要针对基于金属氧化物的 ENMs 提出，吨位是 ENMs 注册的主要标准之一，然而，亚纳米级的 ENMs 正在出现，也许很快就会出现一类新的 ENMs。我们发现，除了缺乏人类暴露于 ENMs 毒性的流行病学证据以及难以分析来自实验模型的毒理学数据之外，在职业环境中空气中 ENMs 浓度的信息缺乏也是改善实验设计的一个重要限制因素。与 ENMs 暴露相关的法规的制定将有助于在不延缓纳米技术进步的情况下为 ENMs 生产提供更安全的工作场所，同时也有助于通过采取适时和正确的纳米废物措施来保护环境，因为这在未来可能是一个重大的环境问题。
