Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease.
作者信息
Geertsma Haley M, Rousseaux Maxime W C
机构信息
Neuroscience Program, University of Ottawa, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Canada.
Department of Cellular and Molecular Medicine, University of Ottawa, Canada; University of Ottawa Brain and Mind Research Institute, Canada; Ottawa Institute of Systems Biology, Canada.
出版信息
EBioMedicine. 2020 Feb;52:102627. doi: 10.1016/j.ebiom.2020.102627. Epub 2020 Jan 22.
Abstract
摘要
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OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.OCIAD1 通过诱导线粒体功能障碍、神经元易损性和突触损伤促进阿尔茨海默病的神经退行性变。
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Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.Asrij/OCIAD1 抑制 CSN5 介导的 p53 降解，维持小鼠造血干细胞静止。
Blood. 2019 May 30;133(22):2385-2400. doi: 10.1182/blood.2019000530. Epub 2019 Apr 5.
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Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy.将阿尔茨海默病中的淀粉样蛋白清除作为一种治疗策略。
Br J Pharmacol. 2019 Sep;176(18):3447-3463. doi: 10.1111/bph.14593. Epub 2019 Mar 11.
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Proteomics. Tissue-based map of the human proteome.蛋白质组学。人类蛋白质组组织图谱。
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