Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, 6200, MD, the Netherlands; The Top Institute of Food and Nutrition (TIFN), Wageningen, 6709, PA, the Netherlands.
Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, 6200, MD, the Netherlands.
Clin Nutr. 2020 Oct;39(10):2998-3004. doi: 10.1016/j.clnu.2020.01.006. Epub 2020 Jan 13.
Effects of weight loss on postprandial vascular function have not been studied so far. We therefore examined (i) effects of diet-induced weight loss on postprandial changes in various vascular function markers after consumption of a mixed meal and (ii) differences between normal-weight and abdominally obese men of comparable age at baseline and after weight loss.
Fifty-four apparently healthy abdominally obese (waist circumference: 102-110 cm) and 25 normal-weight men (waist circumference: <94 cm) participated. The abdominally obese men were randomly allocated to a diet-induced weight-loss program or a no-weight loss control group. Men assigned to the weight-loss program followed a calorie-restricted diet for six weeks targeting a waist circumference of less than 102 cm, followed by a weight-maintenance period for two weeks. The control group maintained their habitual diet and physical activity levels. Measurements were performed before and two hours after consumption of the test meal consisting of two muffins (containing 56.6 g fat) and 300 mL low-fat milk.
The mean weight loss was 10.3 kg in the weight-loss compared with the control group. The postprandial change in flow-mediated vasodilation of the brachial artery (FMD) was significantly higher at baseline in normal-weight as compared with the postprandial change in abdominally obese men (1.89 ± 2.52 versus 0.48 ± 2.50 percentage points; P = 0.027). However, no differences in postprandial changes were observed in the abdominally obese men after weight loss compared with the control treatment. Also, weight reduction did not affect postprandial changes in carotid-to-femoral pulse wave velocity, retinal microvascular caliber properties, or plasma markers of microvascular endothelial function. Even though postprandial increases in triacylglycerol (P = 0.028), insulin (P = 0.029) and C-peptide concentrations (P < 0.001) were reduced in the abdominally obese men following weight loss, postprandial changes in FMD at the end of the weight-loss treatment were still more unfavorable as compared with those observed in normal-weight individuals.
In this trial with abdominally obese men, we did not find effects of diet-induced weight loss on postprandial changes in vascular endothelial function, arterial stiffness and markers of microvascular function. This trial was registered on ClinicalTrials.gov under study number NCT01675401.
目前尚未研究体重减轻对餐后血管功能的影响。因此，我们检测了（i）饮食诱导的体重减轻对混合餐后各种血管功能标志物的餐后变化的影响，以及（ii）基线和体重减轻后，正常体重和腹型肥胖男性之间的差异。
54 名明显健康的腹型肥胖（腰围：102-110cm）和 25 名正常体重男性（腰围：<94cm）参与了研究。将腹型肥胖男性随机分配到饮食诱导的减肥计划或无体重减轻对照组。参加减肥计划的男性遵循热量限制饮食六周，目标是腰围小于 102cm，然后进行两周的维持体重期。对照组保持他们的习惯性饮食和身体活动水平。在食用含有 56.6g 脂肪的两个松饼和 300ml 低脂牛奶的测试餐后两小时进行测量。
与对照组相比，减肥组的平均体重减轻了 10.3kg。与腹型肥胖男性相比，正常体重男性的肱动脉血流介导的血管扩张（FMD）的餐后变化在基线时明显更高（1.89±2.52 与 0.48±2.50 个百分点；P=0.027）。然而，与对照组相比，腹型肥胖男性在体重减轻后餐后变化没有差异。此外，体重减轻对餐后颈动脉-股动脉脉搏波速度、视网膜微血管口径特性或微血管内皮功能的血浆标志物无影响。即使在腹型肥胖男性中，餐后三酰甘油（P=0.028）、胰岛素（P=0.029）和 C 肽浓度（P<0.001）的增加减少，在减肥治疗结束时，FMD 的餐后变化仍然比正常体重个体观察到的更不利。
在这项针对腹型肥胖男性的试验中，我们没有发现饮食诱导的体重减轻对餐后血管内皮功能、动脉僵硬和微血管功能标志物的餐后变化有影响。该试验在 ClinicalTrials.gov 上以研究编号 NCT01675401 注册。
