触珠蛋白表型影响伴有代谢异常的中年腹型肥胖女性饮食诱导减肥的效果。

Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities.

机构信息

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

出版信息

Clin Nutr. 2020 Jan;39(1):225-233. doi: 10.1016/j.clnu.2019.01.019. Epub 2019 Jan 26.

DOI:10.1016/j.clnu.2019.01.019

PMID:30737047

Abstract

BACKGROUND & AIMS: Haptoglobin (Hp) is associated with risks of obesity and cardiometabolic dysfunction; however, the role of the Hp phenotype in diet-induced weight loss remains to be elucidated. This study investigated whether the Hp phenotype contributes to inter-individual variations in body weight reduction as well as changes in the metabolic profile.

METHODS

Secondary data analysis from a randomized controlled trial. In total, 151 abdominally obese Taiwanese women with ≥2 metabolic components were randomized to each of four dietary programs [calorie restriction (CR), calorie restriction plus fish oil supplementation (CRF), calorie restricted meal replacement (CRMR), and calorie restricted meal replacement with fish oil supplementation (CRMRF)] for 12 weeks. Abdominal obesity was defined as a waist circumference (WC) ≥ 80 cm in women. Hp phenotyping was performed by plasma gel electrophoresis.

RESULTS

The prevalence of the Hp 1-1, 2-1, and 2-2 phenotypes were 12.58%, 41.06% and 46.35%, respectively. The mean age was 50.59 ± 12.22 years, and mean reduction in the percent body weight was 4.7% ± 3.8%. The Hp 1-1 phenotype exhibited significant decreases in the WC, body fat mass, plasma insulin levels, free hemoglobin and homeostatic model assessment of insulin resistance (HOMA-IR) compared to the Hp 2-1 or Hp 2-2 phenotypes after adjusting for the baseline age, WC, metabolic syndrome (MetS), and dietary programs (all adjusted p < 0.05). A greater improvement in the prevalence of central obesity and, to a lesser extent, MetS was also found in women with the Hp 1-1 phenotype.

CONCLUSIONS

Obese women with the Hp 1-1 phenotype might obtain greater benefits in terms of reducing abdominal fat and improving insulin sensitivity in response to hypocaloric diet-induced weight reduction. The findings from this study support potential gene-diet interactions affecting weight loss. This trial was registered at ClinicalTrials.gov as NCT01768169.

CLINICAL TRIAL REGISTRY

This trial was registered at ClinicalTrials.gov as NCT01768169.

摘要

背景与目的

触珠蛋白（Hp）与肥胖和心脏代谢功能障碍的风险相关；然而，Hp 表型在饮食诱导的体重减轻中的作用仍有待阐明。本研究旨在探讨 Hp 表型是否有助于个体间体重减轻的差异以及代谢谱的变化。

方法

这是一项随机对照试验的二次数据分析。共有 151 名患有≥2 种代谢成分的台湾腹部肥胖女性被随机分配到以下四种饮食方案中的每一种：热量限制（CR）、热量限制加鱼油补充（CRF）、热量限制代餐（CRMR）和热量限制代餐加鱼油补充（CRMRF），为期 12 周。腹部肥胖定义为女性腰围（WC）≥80cm。Hp 表型通过血浆凝胶电泳进行。

结果

Hp1-1、2-1 和 2-2 表型的患病率分别为 12.58%、41.06%和 46.35%。平均年龄为 50.59±12.22 岁，体重百分比平均下降 4.7%±3.8%。调整基线年龄、WC、代谢综合征（MetS）和饮食方案后，与 Hp2-1 或 Hp2-2 表型相比，Hp1-1 表型的 WC、体脂肪量、血浆胰岛素水平、游离血红蛋白和稳态模型评估的胰岛素抵抗（HOMA-IR）显著降低（所有调整后的 p 值均<0.05）。在 Hp1-1 表型的女性中，中心性肥胖的患病率也得到了更大的改善，而 MetS 的改善程度则较小。