Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX 77843-1114, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA.
Trends Cell Biol. 2020 Mar;30(3):170-172. doi: 10.1016/j.tcb.2020.01.001. Epub 2020 Jan 22.
A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in Developmental Cell, Sundberg et al. reveal that sphingomyelin and a proteoglycan mediate lipoprotein lipase sorting in the TGN.
可溶性蛋白 cargo 在高尔基网络（TGN）水平上如何被分类为不同的囊泡类别的机制描述一直难以捉摸。在最近发表在《发育细胞》杂志上的一项研究中，Sundberg 等人揭示了神经鞘磷脂和蛋白聚糖介导了脂蛋白脂肪酶在 TGN 中的分拣。
