测量人体中的氧化损伤：与癌症和衰老的关系。
Measuring oxidative damage in humans: relation to cancer and ageing.
作者信息
Ames B N
机构信息
Department of Biochemistry, University of California, Berkeley.
出版信息
IARC Sci Publ. 1988(89):407-16.
Many uncertainties remain about the free-radical theory of ageing and the role of oxidative damage to DNA in cancer. The chemistry and biochemistry of radical-induced DNA damage are now well characterized in vitro, but the complexity of in-vivo systems leaves this area still largely unexplored. Measurement of thymine and thymidine glycols in urine may be a means of assaying background levels of radical-induced DNA damage in live organisms. Similar approaches may prove useful for testing some of the predictions of the free-radical theory of ageing and of the contribution of free radicals to cancer.
关于衰老的自由基理论以及氧化损伤在癌症中对DNA的作用，仍存在许多不确定性。自由基诱导的DNA损伤的化学和生物化学在体外现已得到很好的表征，但体内系统的复杂性使得该领域在很大程度上仍未得到探索。测量尿液中的胸腺嘧啶和胸腺嘧啶二醇可能是一种测定活生物体中自由基诱导的DNA损伤背景水平的方法。类似的方法可能被证明对检验衰老的自由基理论的一些预测以及自由基对癌症的影响有用。
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