头花蓼根茎中的甾体皂苷及其对 HepG2 细胞的细胞毒性。
Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells.
机构信息
Beijing Institute of Radiation Medicine, Beijing 100850, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Beijing Institute of Radiation Medicine, Beijing 100850, China.
出版信息
Steroids. 2020 Apr;156:108587. doi: 10.1016/j.steroids.2020.108587. Epub 2020 Jan 23.
A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-S14 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.
对延龄草属植物的根茎进行植物化学研究，分离得到了 14 个新的甾体皂苷，分别命名为 trillitschosides S1-S14（1-14），以及 10 个已知类似物（15-24）。其结构主要通过光谱分析以及必要的化学证据确定。所有分离得到的化合物均进行了对 HepG2 细胞的细胞毒性筛选，结果表明，只有已知化合物 21-24 对 HepG2 细胞具有显著的细胞毒性活性，明显优于阳性对照 5-FU。
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