从土茯苓根茎中分离得到具有细胞毒性的甾体皂苷。
Steroidal saponins with cytotoxic effects from the rhizomes of Asparagus cochinchinensis.
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
出版信息
Bioorg Chem. 2021 Oct;115:105237. doi: 10.1016/j.bioorg.2021.105237. Epub 2021 Aug 4.
In the ongoing research on potent antitumor agents from the rhizomes of Asparagus cochinchinensis, seven undescribed steroidal saponins asparagusoside A-G (1-7), along with twenty known ones (8-27), were isolated and elucidated via analyzing their 1D, 2D NMR, mass spectroscopic data and chemical methods. All isolated compounds were evaluated for their cytotoxic effects against human large cell lung carcinoma cells (NCI-H460) in vitro. Among them, compounds 7, 9 and 27 showed more significant antitumor activities than the positive control cisplatin (11.56 μM) with IC values of 1.39, 3.04, and 2.25 μM, respectively. Further research about asparagusoside G (7) showed G0/G1 arrest in NCI-H460 cell line cycle and induced cell death by apoptosis in a dose‑dependent way.
在从天门冬科植物土茯苓的根茎中寻找有效抗肿瘤药物的研究中，分离并通过分析其 1D、2D NMR、质谱和化学方法鉴定了 7 种未描述的甾体皂苷土茯苓苷 A-G（1-7），以及 20 种已知的甾体皂苷（8-27）。所有分离得到的化合物都在体外进行了对人非小细胞肺癌细胞（NCI-H460）的细胞毒性评估。其中，化合物 7、9 和 27 的抗肿瘤活性强于阳性对照顺铂（IC 值分别为 1.39、3.04 和 2.25 μM）。对土茯苓苷 G（7）的进一步研究表明，其可使 NCI-H460 细胞周期停滞在 G0/G1 期，并呈剂量依赖性诱导细胞凋亡死亡。
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