肉桂酸对 HepG2 细胞和高脂饮食喂养小鼠的抗肥胖作用。
Anti-obesity effect of trans-cinnamic acid on HepG2 cells and HFD-fed mice.
机构信息
Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
出版信息
Food Chem Toxicol. 2020 Mar;137:111148. doi: 10.1016/j.fct.2020.111148. Epub 2020 Jan 23.
Trans-cinnamic acid (tCA) is a phenylpropenoic acid, which occurs naturally in a number of plants. In this study, the anti-obese effects of tCA were evaluated in oleic acid (OA)-induced HepG2 cells and high fat diet (HFD)-fed mice. The results showed tCA treatment significantly decreased lipid accumulation in HepG2 cells exposed to OA. Furthermore, administration of tCA (40 mg/kg/day) curbed body weight gains, reduced liver and adipose tissue weight, and ameliorated hepatic steatosis and adipose hypertrophy in mice fed with HFD. In addition, significant decrease in plasma levels of TG, TC and LDL-C were also observed in HFD-fed mice with tCA treatment. Collectively, tCA may play a vital role in preventing and treating diet induced obesity.
反式肉桂酸（tCA）是一种肉桂酸，天然存在于许多植物中。在这项研究中，评估了 tCA 在油酸（OA）诱导的 HepG2 细胞和高脂肪饮食（HFD）喂养的小鼠中的抗肥胖作用。结果表明，tCA 处理可显著减少 OA 暴露的 HepG2 细胞中的脂质积累。此外，给予 tCA（40mg/kg/天）可抑制 HFD 喂养小鼠的体重增加，减少肝脏和脂肪组织重量，并改善肝脂肪变性和脂肪肥大。此外，在给予 tCA 治疗的 HFD 喂养小鼠中，还观察到血浆 TG、TC 和 LDL-C 水平显著降低。总之，tCA 可能在预防和治疗饮食诱导的肥胖中发挥重要作用。
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