• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于非靶向代谢组学的网络药理学揭示了发酵糙米的抗肥胖功效。

Untargeted metabolomics-based network pharmacology reveals fermented brown rice towards anti-obesity efficacy.

作者信息

Barathikannan Kaliyan, Chelliah Ramachandran, Vinothkanna Annadurai, Prathiviraj Ragothaman, Tyagi Akanksha, Vijayalakshmi Selvakumar, Lim Min-Jin, Jia Ai-Qun, Oh Deog- Hwan

机构信息

Agricultural and Life Science Research Institute, Kangwon National University, Chuncheon, 24341, Korea.

Saveetha School of Engineering, Saveetha (SIMATS) University, Tamil Nadu, 600124, India.

出版信息

NPJ Sci Food. 2024 Mar 30;8(1):20. doi: 10.1038/s41538-024-00258-x.

DOI:10.1038/s41538-024-00258-x
PMID:38555366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10981755/
Abstract

There is a substantial rise in the global incidence of obesity. Brown rice contains metabolic substances that can help minimize the prevalence of obesity. This study evaluated nine brown rice varieties using probiotic fermentation using Pediococcus acidilacti MNL5 to enhance bioactive metabolites and their efficacy. Among the nine varieties, FBR-1741 had the highest pancreatic lipase inhibitory efficacy (87.6 ± 1.51%), DPPH assay (358.5 ± 2.80 mg Trolox equiv./100 g, DW), and ABTS assay (362.5 ± 2.32 mg Trolox equiv./100 g, DW). Compared to other fermented brown rice and FBR-1741 varieties, UHPLC-Q-TOF-MS/MS demonstrated significant untargeted metabolite alterations. The 17 most abundant polyphenolic metabolites in the FBR-1741 variety and 132 putative targets were assessed for obesity-related target proteins, and protein interaction networks were constructed using the Cystoscope software. Network pharmacology analysis validated FBR-1741 with active metabolites in the C. elegans obesity-induced model. Administration of FBR-1741 with ferulic acid improved lifespan decreased triglycerides, and suppressed the expression of fat-related genes. The enhanced anti-obesity properties of FBR-1741 suggest its implementation in obesity-functional food.

摘要

全球肥胖发病率大幅上升。糙米含有有助于降低肥胖患病率的代谢物质。本研究使用嗜酸乳杆菌MNL5对9个糙米品种进行益生菌发酵，以增强生物活性代谢物及其功效。在这9个品种中，FBR - 1741具有最高的胰脂肪酶抑制功效（87.6±1.51%）、DPPH测定值（358.5±2.80毫克 Trolox 当量/100克，干重）和ABTS测定值（362.5±2.32毫克 Trolox 当量/100克，干重）。与其他发酵糙米和FBR - 1741品种相比，超高效液相色谱-四极杆飞行时间串联质谱（UHPLC-Q-TOF-MS/MS）显示出显著的非靶向代谢物变化。对FBR - 1741品种中17种最丰富的多酚类代谢物和132个推定靶点进行了肥胖相关靶蛋白评估，并使用Cystoscope软件构建了蛋白质相互作用网络。网络药理学分析在秀丽隐杆线虫肥胖诱导模型中验证了FBR - 1741与活性代谢物的关系。用阿魏酸施用FBR - 1741可延长寿命、降低甘油三酯，并抑制脂肪相关基因的表达。FBR - 1741增强的抗肥胖特性表明其可应用于肥胖功能性食品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/ed720884caec/41538_2024_258_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/e0d25f3f54db/41538_2024_258_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/82056c0f976d/41538_2024_258_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/49a55ab2b5a2/41538_2024_258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/7364c6d0d131/41538_2024_258_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/7c3ef402f3e0/41538_2024_258_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/fda8fe4c82c6/41538_2024_258_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/ed720884caec/41538_2024_258_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/e0d25f3f54db/41538_2024_258_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/82056c0f976d/41538_2024_258_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/49a55ab2b5a2/41538_2024_258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/7364c6d0d131/41538_2024_258_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/7c3ef402f3e0/41538_2024_258_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/fda8fe4c82c6/41538_2024_258_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23e/10981755/ed720884caec/41538_2024_258_Fig7_HTML.jpg

相似文献

1
Untargeted metabolomics-based network pharmacology reveals fermented brown rice towards anti-obesity efficacy.基于非靶向代谢组学的网络药理学揭示了发酵糙米的抗肥胖功效。
NPJ Sci Food. 2024 Mar 30;8(1):20. doi: 10.1038/s41538-024-00258-x.
2
Antiobesity and Antioxidative Effect of Fermented Brown Rice Using In Vitro with In Vivo Model.利用体外和体内模型研究发酵糙米的抗肥胖和抗氧化作用
Life (Basel). 2023 Jan 29;13(2):374. doi: 10.3390/life13020374.
3
Untargeted Metabolomics and Gut Microbiota Modulation Study of Fermented Brown Rice for Obesity.发酵糙米对肥胖症的非靶向代谢组学及肠道微生物群调节研究
ACS Omega. 2024 Aug 28;9(36):37636-37649. doi: 10.1021/acsomega.4c01203. eCollection 2024 Sep 10.
4
Untargeted metabolomics of fermented onion (Allium cepa L) using UHPLC Q-TOF MS/MS reveals anti-obesity metabolites and in vivo efficacy in Caenorhabditis elegans.利用 UHPLC Q-TOF MS/MS 进行非靶向代谢组学分析，揭示发酵洋葱（Allium cepa L）的抗肥胖代谢产物及其在秀丽隐杆线虫体内的功效。
Food Chem. 2023 Mar 15;404(Pt B):134710. doi: 10.1016/j.foodchem.2022.134710. Epub 2022 Oct 21.
5
Fermented Brown Rice: A Product with Enhanced Bioactive Compounds and Antioxidant Potential.发酵糙米：一种具有增强生物活性化合物和抗氧化潜力的产品。
Antioxidants (Basel). 2021 Jul 5;10(7):1077. doi: 10.3390/antiox10071077.
6
Untargeted Metabolomics of Korean Fermented Brown Rice Using UHPLC Q-TOF MS/MS Reveal an Abundance of Potential Dietary Antioxidative and Stress-Reducing Compounds.采用超高效液相色谱-四极杆飞行时间串联质谱法对韩国发酵糙米进行非靶向代谢组学分析，揭示了大量潜在的膳食抗氧化和减压化合物。
Antioxidants (Basel). 2021 Apr 19;10(4):626. doi: 10.3390/antiox10040626.
7
Characterization of Macrophage-Activating Polysaccharide Isolated from Fermented Brown Rice.从发酵糙米中分离出的巨噬细胞激活多糖的特性
J Med Food. 2016 Dec;19(12):1147-1154. doi: 10.1089/jmf.2016.3742. Epub 2016 Nov 22.
8
Untargeted Metabolomics of Fermented Rice Using UHPLC Q-TOF MS/MS Reveals an Abundance of Potential Antihypertensive Compounds.基于超高效液相色谱-四极杆飞行时间串联质谱联用技术的发酵米非靶向代谢组学揭示了大量潜在的抗高血压化合物。
Foods. 2020 Jul 27;9(8):1007. doi: 10.3390/foods9081007.
9
Effects of Germination, Fermentation and Extrusion on the Nutritional, Cooking and Sensory Properties of Brown Rice Products: A Comparative Study.发芽、发酵和挤压对糙米制品营养、烹饪及感官特性的影响：一项比较研究。
Foods. 2023 Apr 5;12(7):1542. doi: 10.3390/foods12071542.
10
Comparative Analysis of Antioxidant Compounds and Antioxidative Properties of Thai Indigenous Rice: Effects of Rice Variety and Processing Condition.泰国本土大米的抗氧化化合物和抗氧化性能比较分析：品种和加工条件的影响。
Molecules. 2022 Aug 14;27(16):5180. doi: 10.3390/molecules27165180.

引用本文的文献

1
High-Expansion Natural Composite Films for Controlled Delivery of Hydroxycitric Acid in Obesity Therapy.用于肥胖治疗中羟基柠檬酸控释的高膨胀天然复合膜
Polymers (Basel). 2025 Jun 18;17(12):1697. doi: 10.3390/polym17121697.
2
Limosilactobacillus reuteri fermented brown rice alleviates anxiety improves cognition and modulates gut microbiota in stressed mice.罗伊氏乳杆菌发酵糙米可缓解应激小鼠的焦虑、改善认知并调节肠道微生物群。
NPJ Sci Food. 2025 Jan 11;9(1):5. doi: 10.1038/s41538-025-00369-z.
3
Untargeted Metabolomics and Gut Microbiota Modulation Study of Fermented Brown Rice for Obesity.

本文引用的文献

1
Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction.内源性 DAF-16 时空活性定量预测饮食限制诱导的寿命延长。
Commun Biol. 2023 Feb 20;6(1):203. doi: 10.1038/s42003-023-04562-2.
2
Antioxidant activities of novel peptides from Limosilactobacillus reuteri fermented brown rice: A combined in vitro and in silico study.来自发酵糙米的罗伊氏乳杆菌新型肽的抗氧化活性：一项体外和计算研究的联合研究。
Food Chem. 2023 Mar 15;404(Pt B):134747. doi: 10.1016/j.foodchem.2022.134747. Epub 2022 Oct 30.
3
GC-MS and Network Pharmacology Analysis of the Ayurvedic Fermented Medicine, Chandanasava, Against Chronic Kidney and Cardiovascular Diseases.
发酵糙米对肥胖症的非靶向代谢组学及肠道微生物群调节研究
ACS Omega. 2024 Aug 28;9(36):37636-37649. doi: 10.1021/acsomega.4c01203. eCollection 2024 Sep 10.
4
Secondary metabolite profiling using HR-LCMS, antioxidant and anticancer activity of PSMS6 methanolic extract: and study.使用高分辨液相色谱-质谱联用技术进行次生代谢产物谱分析、PSMS6甲醇提取物的抗氧化和抗癌活性：以及研究。
Biotechnol Rep (Amst). 2024 May 2;42:e00842. doi: 10.1016/j.btre.2024.e00842. eCollection 2024 Jun.
基于 GC-MS 和网络药理学分析阿育吠陀发酵药物 Chandanasava 对慢性肾脏病和心血管疾病的作用。
Appl Biochem Biotechnol. 2023 May;195(5):2803-2828. doi: 10.1007/s12010-022-04242-7. Epub 2022 Nov 23.
4
Untargeted metabolomics of fermented onion (Allium cepa L) using UHPLC Q-TOF MS/MS reveals anti-obesity metabolites and in vivo efficacy in Caenorhabditis elegans.利用 UHPLC Q-TOF MS/MS 进行非靶向代谢组学分析，揭示发酵洋葱（Allium cepa L）的抗肥胖代谢产物及其在秀丽隐杆线虫体内的功效。
Food Chem. 2023 Mar 15;404(Pt B):134710. doi: 10.1016/j.foodchem.2022.134710. Epub 2022 Oct 21.
5
Identification of hub genes and candidate herbal treatment in obesity through integrated bioinformatic analysis and reverse network pharmacology.通过整合生物信息学分析和反向网络药理学鉴定肥胖症的枢纽基因和候选草药治疗药物。
Sci Rep. 2022 Oct 12;12(1):17113. doi: 10.1038/s41598-022-22112-4.
6
Ferulic Acid Prevents Nonalcoholic Fatty Liver Disease by Promoting Fatty Acid Oxidation and Energy Expenditure in C57BL/6 Mice Fed a High-Fat Diet.阿魏酸通过促进高脂肪饮食喂养的 C57BL/6 小鼠的脂肪酸氧化和能量消耗来预防非酒精性脂肪肝病。
Nutrients. 2022 Jun 18;14(12):2530. doi: 10.3390/nu14122530.
7
Quantification of Amino Acids, Phenolic Compounds Profiling from Nine Rice Varieties and Their Antioxidant Potential.九个水稻品种的氨基酸定量、酚类化合物分析及其抗氧化潜力
Antioxidants (Basel). 2022 Apr 25;11(5):839. doi: 10.3390/antiox11050839.
8
Bioinformatics Screening of Potential Biomarkers from mRNA Expression Profiles to Discover Drug Targets and Agents for Cervical Cancer.基于 mRNA 表达谱的生物信息学筛选宫颈癌潜在生物标志物以发现药物靶点和药物。
Int J Mol Sci. 2022 Apr 2;23(7):3968. doi: 10.3390/ijms23073968.
9
African fermented foods: overview, emerging benefits, and novel approaches to microbiome profiling.非洲发酵食品：概述、新益处及微生物群落分析新方法
NPJ Sci Food. 2022 Feb 18;6(1):15. doi: 10.1038/s41538-022-00130-w.
10
Anti-Obesity Efficacy of MNL5 in Gut Model.MNL5在肠道模型中的抗肥胖功效
Int J Mol Sci. 2022 Jan 24;23(3):1276. doi: 10.3390/ijms23031276.