饮食碳水化合物摄入量与骨折风险的系统评价和观察性研究荟萃分析。
Dietary carbohydrate intake and risk of bone fracture: a systematic review and meta-analysis of observational studies.
机构信息
Faculty of Land and Food Systems, University of British Columbia, British Columbia, Canada; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Public Health. 2020 Apr;181:102-109. doi: 10.1016/j.puhe.2019.12.001. Epub 2020 Jan 23.
OBJECTIVE
Despite growing evidence for the association between other dietary macronutrients and bone health, limited and inconsistent knowledge is available regarding carbohydrate intake. In this systematic review and meta-analysis, we purposed to clarify and synthesize the knowledge about the relation between carbohydrate intake and the risk of fracture.
STUDY DESIGN
Systematic review and meta-analysis of observational studies.
METHODS
In this study, PubMed and Scopus were used to conduct a comprehensive search for articles published up to September 2018. The screening was done independently by two authors. Pooled effect sizes were calculated using fixed and random effect models for the highest versus lowest intake categories. The dose-response nature of the relationship was also investigated.
RESULTS
No association was observed between carbohydrate intake and the risk of fracture in high versus low intake meta-analysis (overall relative risk [RR]: 1.24; 95% confidence interval [95% CI]: 0.84-1.84; P = 0.27) with moderate heterogeneity (I = 57.7%, P = 0.05). Moreover, there was no relationship between carbohydrate intake and the risk of fracture in both linear (overall RR: 1.00; 95% CI: 0.94-1.05; P = 0.88) (I = 68.1%, P = 0.48) and nonlinear (P = 0.14) models.
CONCLUSION
No association was observed between carbohydrate intake and the risk of fracture.
目的
尽管有越来越多的证据表明其他膳食宏量营养素与骨骼健康之间存在关联，但关于碳水化合物摄入量的知识有限且不一致。在本系统评价和荟萃分析中，我们旨在阐明和综合有关碳水化合物摄入量与骨折风险之间关系的知识。
研究设计
对观察性研究进行系统评价和荟萃分析。
方法
本研究使用 PubMed 和 Scopus 对截至 2018 年 9 月发表的文章进行了全面检索。两名作者独立进行筛选。使用固定效应模型和随机效应模型计算最高与最低摄入量类别之间的汇总效应大小。还研究了这种关系的剂量反应性质。
结果
在高 versus 低摄入量荟萃分析中（总体相对风险 [RR]：1.24；95%置信区间 [95%CI]：0.84-1.84；P = 0.27），碳水化合物摄入量与骨折风险之间没有关联，且存在中度异质性（I = 57.7%，P = 0.05）。此外，碳水化合物摄入量与骨折风险之间也没有线性（总体 RR：1.00；95%CI：0.94-1.05；P = 0.88）（I = 68.1%，P = 0.48）和非线性（P = 0.14）模型之间存在关系。
结论
碳水化合物摄入量与骨折风险之间没有关联。
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