Sakaguchi T, Arase K, Bray G A
Department of Medicine, University of Southern California, School of Medicine, Los Angeles 90033.
Int J Obes. 1988;12(4):285-91.
Following ventromedial hypothalamic lesions, food intake increased from 60 to slightly more than 77 kcal/day during the first 6 days. Body weight increased and sympathetic activity, as measured by the electrical firing rate of efferent nerves to interscapular brown adipose tissue, decreased significantly. During a 6-day period of intragastric overfeeding in which animals with hypothalamic lesions received 60 kcal for the first day and 80 kcal for the remaining 5 days, the VMH-lesioned animals gained significantly more weight than the intact, sham-lesioned controls. This difference in weight gain was paralleled by the increased weight of liver and white adipose tissue. The lesioned animals showed a highly significant reduction in sympathetic activity compared to the normal or slightly increased values observed in the sham-lesioned animals. These studies are consistent with the hypothesis that food-induced increases in sympathetic activity are modulated by the ventromedial hypothalamus.
下丘脑腹内侧核损伤后，在最初6天内，食物摄入量从每天60千卡增加到略高于77千卡。体重增加，而通过肩胛间棕色脂肪组织传出神经的电发放率测量的交感神经活动显著降低。在为期6天的胃内过量喂食期间，下丘脑损伤的动物第一天接受60千卡，其余5天接受80千卡，VMH损伤的动物比完整的、假手术对照动物体重增加显著更多。体重增加的这种差异与肝脏和白色脂肪组织重量的增加平行。与假手术动物中观察到的正常或略有增加的值相比，损伤动物的交感神经活动显著降低。这些研究与食物诱导的交感神经活动增加受下丘脑腹内侧核调节的假说一致。
