Mallya Sandeep, Gangadhar Varsha, Aldrin Sophia Evangeline, Acharya Meghana, Kabekkodu Shama Prasada, Kolathur Kiran Kumar, Chakrabarty Sanjiban
Department of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Cancer Biol Ther. 2025 Dec;26(1):2501345. doi: 10.1080/15384047.2025.2501345. Epub 2025 May 12.
The epidemic of obesity is a growing concern and is one of the major risk factors for several chronic diseases, including several types of cancers. The correlation of breast cancer with obesity has been extensively studied and involves an interplay of hormonal, metabolic, and genetic factors explored in this review. Inflammation and hormone dysregulation play an important role in promoting a protumorigenic environment through adipose tissue, which is involved in energy storage and functions as an endocrine organ. As a result, various cytokines, primarily proinflammatory in nature, are released, resulting in low-grade inflammation promoting tumor growth. Additionally, obese conditions also induce imbalances in hormones, particularly estrogen and insulin, both of which drive carcinogenesis. Genetic components such as single nucleotide polymorphisms also play critical roles in modulating the correlation between obesity and breast cancer. This review provides a comprehensive overview of various mechanisms underlying obesity and breast cancer incidence and progression.
肥胖流行是一个日益受到关注的问题，是包括几种癌症在内的多种慢性疾病的主要危险因素之一。乳腺癌与肥胖之间的相关性已得到广泛研究，本综述探讨了其中涉及的激素、代谢和遗传因素的相互作用。炎症和激素失调通过脂肪组织在促进肿瘤发生环境中起重要作用，脂肪组织参与能量储存并作为内分泌器官发挥作用。结果，释放出各种主要具有促炎性质的细胞因子，导致促进肿瘤生长的低度炎症。此外，肥胖状况还会导致激素失衡，尤其是雌激素和胰岛素，二者都会推动癌症发生。单核苷酸多态性等遗传成分在调节肥胖与乳腺癌之间的相关性方面也起着关键作用。本综述全面概述了肥胖与乳腺癌发生及进展的各种潜在机制。
