Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.
Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.
Int J Biol Macromol. 2021 Feb 15;170:751-767. doi: 10.1016/j.ijbiomac.2020.12.214. Epub 2021 Jan 4.
Spherical aerogels are not easily broken during use and are easier to transport and store which can be used as templates for drug delivery. This review summarizes the possible approaches for the preparation of aerogel beads and microspheres based on chitosan and cellulose, an overview to the methods of manufacturing droplets is presented, afterwards, the transition mechanisms from sol to a spherical gel are reviewed in detail followed by different drying processes to obtain spherical aerogels with porous structures. Additionally, a specific focus is given to aerogel beads and microspheres to be regarded as drug delivery carriers. Furthermore, a core/shell architecture of aerogel beads and microspheres for controlled drug release is described and subjected to inspire readers to create novel drug release system. Finally, the conclusions and outlooks of aerogel beads and microspheres for drug delivery are summarized.
球形气凝胶在使用过程中不易破裂，并且更便于运输和储存，可用作药物输送的模板。本综述总结了基于壳聚糖和纤维素制备气凝胶珠和微球的可能方法，介绍了制造液滴的方法概述，然后详细回顾了从溶胶到球形凝胶的转变机制，随后介绍了获得具有多孔结构的球形气凝胶的不同干燥工艺。此外，特别关注作为药物输送载体的气凝胶珠和微球。此外，还描述了用于控制药物释放的气凝胶珠和微球的核/壳结构，并启发读者创造新的药物释放系统。最后，总结了用于药物输送的气凝胶珠和微球的结论和展望。
