高尿酸血症模型大鼠肠道ABCG2表达与尿酸代谢
ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat.
作者信息
Morimoto Chikayuki, Tamura Yoshifuru, Asakawa Shinichiro, Kuribayashi-Okuma Emiko, Nemoto Yoshikazu, Li Jinping, Murase Takayo, Nakamura Takashi, Hosoyamada Makoto, Uchida Shunya, Shibata Shigeru
机构信息
Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Pharmacological Study Group, Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho, Mie, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2020;39(5):744-759. doi: 10.1080/15257770.2019.1694684. Epub 2020 Jan 25.
To elucidate roles of the intestine in uric acid (UA) metabolism, we examined ABCG2 expression, tissue UA content and xanthine oxidoreductase (XOR) activity in different intestinal segments. Male SD rats were assigned to control group or oxonic acid-induced hyperuricemia (HUA) group. In control rats, ABCG2 was present both in villi and crypts in each segment. Tissue UA content and XOR activity were relatively high in duodenum and jejunum. However, in HUA rats, tissue UA content was significantly elevated in the ileum, whereas it remained unaltered in other segments. Moreover, ABCG2 expression in the HUA group was upregulated both in the villi and crypts of the ileum. These data indicate that the ileum may play an important role in the extra-renal UA excretion.
为阐明肠道在尿酸（UA）代谢中的作用，我们检测了不同肠段中ABCG2的表达、组织尿酸含量和黄嘌呤氧化还原酶（XOR）活性。将雄性SD大鼠分为对照组或氧嗪酸诱导的高尿酸血症（HUA）组。在对照大鼠中，各肠段的绒毛和隐窝中均存在ABCG2。十二指肠和空肠中的组织尿酸含量和XOR活性相对较高。然而，在HUA大鼠中，回肠中的组织尿酸含量显著升高，而其他肠段则保持不变。此外，HUA组回肠绒毛和隐窝中的ABCG2表达均上调。这些数据表明，回肠可能在肾外尿酸排泄中起重要作用。
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