Faculty of Science and Engineering, University of Chester, Thornton Science Park, ChesterCH2 4NU, UK.
Nutr Res Rev. 2020 Jun;33(1):121-133. doi: 10.1017/S0954422419000258. Epub 2020 Jan 27.
The last few decades have witnessed a global rise in the number of older individuals. Despite this demographic shift, morbidity within this population group is high. Many factors influence healthspan; however, an obesity pandemic is emerging as a significant determinant of older people's health. It is well established that obesity adversely affects several metabolic systems. However, due to its close association with overall cardiometabolic health, the impact that obesity has on cholesterol metabolism needs to be recognised. The aim of the present review is to critically discuss the effects that obesity has on cholesterol metabolism and to reveal its significance for healthy ageing.
过去几十年见证了全球老年人口数量的增长。尽管这种人口结构变化，这个年龄群体的发病率仍然很高。许多因素影响健康寿命；然而，肥胖症的流行正成为老年人健康的一个重要决定因素。肥胖症对多个代谢系统有不利影响，这一点已得到充分证实。然而，由于它与整体心血管代谢健康密切相关，肥胖症对胆固醇代谢的影响需要得到认识。本综述的目的是批判性地讨论肥胖症对胆固醇代谢的影响，并揭示其对健康老龄化的意义。
