Guidollet J, Louisot P, Amiel M, Limam K
INSERM U. 189, Lyon, France.
Invest Radiol. 1988 Sep;23 Suppl 1:S171-3. doi: 10.1097/00004424-198809001-00029.
Several conventional and new contrast media were studied in vitro in order to evaluate their effects on acetylcholine hydrolase. Iohexol proved to be the most potent inhibitor of cholinesterase; all other conventional ionic agents are not inhibitors or they are weak inhibitors at the concentrations that are apparently achieved locally in clinical practice. The full clinical significance of the relationship between cholinesterase inhibition in vitro and contrast media toxicity must be reviewed.
为了评估几种传统和新型造影剂对乙酰胆碱水解酶的影响，进行了体外研究。碘海醇被证明是最有效的胆碱酯酶抑制剂；所有其他传统离子型造影剂在临床实践中局部所能达到的浓度下，都不是抑制剂，或者只是弱抑制剂。体外胆碱酯酶抑制与造影剂毒性之间关系的全部临床意义必须重新审视。
