Department of Dental Hygiene, College of Bioecological Health, Shinhan University, Uijeongbu, Republic of Korea.
J Periodontol. 2020 Sep;91(9):1186-1193. doi: 10.1002/JPER.19-0311. Epub 2020 Feb 14.
Using the database of the National Health Insurance Service-National Sample Cohort (NHIS-NSC), we aimed to assess the relationship between the prevalence of rheumatoid arthritis (RA) and periodontitis.
Participants aged ≥19 years with a previous health check-up at the NHIS between 2009 and 2015 were selected. In total, 559,280 participants were included after implementing appropriate exclusion criteria. The Chi-squared test was used to compare the general and health-related characteristics of participants with and without RA or periodontitis. Univariate and multivariate logistic regression analyses with consecutive adjustment for confounders, were used to assess the association between the prevalence of rheumatoid arthritis and periodontitis.
The prevalence of rheumatoid arthritis in patients with and without periodontitis was 6.2% and 5.2%, respectively. The prevalence of periodontitis in patients with and without rheumatoid arthritis was 19.6% and 16.6%, respectively. The possibility of having rheumatoid arthritis was greater in patients with periodontitis than in individuals without periodontitis (odds ratio [OR]; 1.22, P <0.001), and remained high (OR; 1.07, P <0.001) after adjusting for confounders.
Our results revealed a significant association between the prevalence of rheumatoid arthritis and periodontitis.
本研究利用国民健康保险服务-国家样本队列（NHIS-NSC）数据库，旨在评估类风湿关节炎（RA）与牙周炎的患病率之间的关系。
选择 2009 年至 2015 年在 NHIS 进行过健康检查的年龄≥19 岁的参与者。实施适当的排除标准后，共纳入 559280 名参与者。采用卡方检验比较有和无 RA 或牙周炎的参与者的一般和与健康相关的特征。采用单变量和多变量逻辑回归分析，连续调整混杂因素，评估类风湿关节炎和牙周炎患病率之间的关联。
有和无牙周炎的 RA 患病率分别为 6.2%和 5.2%。有和无 RA 的牙周炎患病率分别为 19.6%和 16.6%。与无牙周炎的个体相比，患有牙周炎的个体发生 RA 的可能性更大（优势比 [OR]；1.22，P<0.001），并且在调整混杂因素后仍然较高（OR；1.07，P<0.001）。
我们的结果表明 RA 与牙周炎的患病率之间存在显著关联。
