School of Agriculture, Yangtze University, Jingzhou, China.
Institute of Pesticides, Yangtze University, Jingzhou, China.
Nat Prod Res. 2021 Nov;35(22):4373-4379. doi: 10.1080/14786419.2020.1716347. Epub 2020 Jan 25.
To develop new phenazine carboxylic acid derivatives with better phloem mobility, five novel 7-amino acid substituted phenazine-1-carboxylic acids were synthesised by introducing amino acids into PCA at the 7-position. The phloem mobility experiments in seedlings showed that retaining the carboxyl group of PCA and conjugating amino acids to its phenazine ring can also endow PCA with phloem mobility. Comparing our previous research, we found the amino acids substituted at 7-position on phenazine ring of PCA could clearly enhance the phloem mobility of PCA than that of amino acids conjugated with carboxyl group. Especially, the phloem transport concentration of the compound 7-L-isoleucine substituted PCA () was 21 times higher than PCA-L-isoleucine conjugate (). These data suggest that the introduction of amino acids at different structural sites on the phenazine ring could effectively enhance the phloem mobility of PCA and it is worth a further study.
为了开发具有更好韧皮部移动性的新型吩嗪羧酸衍生物，通过在 PCA 的 7-位引入氨基酸，合成了 5 种新型 7-氨基酸取代的吩嗪-1-羧酸。在幼苗中的韧皮部移动性实验表明，保留 PCA 的羧基并将氨基酸连接到其吩嗪环上也可以赋予 PCA 韧皮部移动性。与我们之前的研究相比，我们发现 PCA 吩嗪环 7-位取代的氨基酸明显比与羧基连接的氨基酸更能增强 PCA 的韧皮部移动性。特别是，化合物 7-L-异亮氨酸取代 PCA（）的韧皮部运输浓度比 PCA-L-异亮氨酸缀合物（）高 21 倍。这些数据表明，在吩嗪环的不同结构位点引入氨基酸可以有效增强 PCA 的韧皮部移动性，值得进一步研究。
