Effect of introducing amino acids into phenazine-1-carboxylic acid on phloem mobility.

To develop new phenazine carboxylic acid derivatives with better phloem mobility, five novel 7-amino acid substituted phenazine-1-carboxylic acids were synthesised by introducing amino acids into PCA at the 7-position. The phloem mobility experiments in seedlings showed that retaining the carboxyl group of PCA and conjugating amino acids to its phenazine ring can also endow PCA with phloem mobility. Comparing our previous research, we found the amino acids substituted at 7-position on phenazine ring of PCA could clearly enhance the phloem mobility of PCA than that of amino acids conjugated with carboxyl group. Especially, the phloem transport concentration of the compound 7-L-isoleucine substituted PCA () was 21 times higher than PCA-L-isoleucine conjugate (). These data suggest that the introduction of amino acids at different structural sites on the phenazine ring could effectively enhance the phloem mobility of PCA and it is worth a further study.