Schomburgkixanthone，一种来自的小桐子嫩枝的新型双黄酮。

Schomburgkixanthone, a novel bixanthone from the twigs of .

机构信息

Institute of Environment-Energy Technology, Sai Gon University, Ho Chi Minh City, Vietnam.

Department of Chemistry, Ho Chi Minh University of Education, Ho Chi Minh City, Vietnam.

出版信息

Nat Prod Res. 2021 Nov;35(21):3613-3618. doi: 10.1080/14786419.2020.1716351. Epub 2020 Jan 25.

DOI:10.1080/14786419.2020.1716351

PMID:31984782

Abstract

A novel bixanthone, named schomburgkixanthone (), was isolated from the twigs of , along with six known compounds, griffipavixanthone (), 4-hydroxyxanthone (), 2-hydroxyxanthone (), 1,6-dihydroxyxanthone (), 1,7-dihydroxyxanthone (), and 1,3,5-trihydroxyxanthone (). The structure of was identified by the application of NMR and MS data analyses and comparison with previous reports. Compound showed the most powerful inhibition of rat intestinal -glucosidase, with IC values of 0.79 for maltase and 1.81 mM for sucrase. Compound most strongly inhibited sucrase, with an IC value of 4.58 mM.

摘要

从的小枝中分离得到一种新的双黄酮类化合物，命名为 schomburgkixanthone ()，同时分离得到 6 种已知化合物，分别为 griffipavixanthone ()、4-羟基黄烷酮 ()、2-羟基黄烷酮 ()、1,6-二羟基黄烷酮 ()、1,7-二羟基黄烷酮 ()和 1,3,5-三羟基黄烷酮 ()。通过 NMR 和 MS 数据分析，并与以前的报道进行比较，确定了的结构。化合物对大鼠肠 -葡萄糖苷酶的抑制活性最强，麦芽糖酶的 IC 值为 0.79，蔗糖酶的 IC 值为 1.81 mM。化合物对蔗糖酶的抑制活性最强，IC 值为 4.58 mM。