Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Periodontology, Faculty of Odontology, Malmö University, Malmö, Sweden.
J Periodontal Res. 2020 Aug;55(4):496-502. doi: 10.1111/jre.12735. Epub 2020 Jan 27.
The present study aimed to evaluate the histological outcome of tunnel β-TCP blocks grafting in extraction sockets missing the buccal bone wall, after 6 months of healing.
Tunnel β-tricalcium phosphate (β-TCP) blocks made of randomly organized tunnel-shaped β-TCP ceramics appeared promising for alveolar ridge preservation in tooth extraction sockets missing the buccal bone, in a previous study in dogs, with a 2-month healing time.
In six beagle dogs, the maxillary first premolars were extracted and the buccal bone was surgically removed to create bone defects of 4 mm (mesio-distal) × 5 mm (apico-coronal) × 4 mm (bucco-palatal). Thus, extraction sockets missing the buccal bone plate were grated with tunnel β-TCP blocks (test) or left empty for spontaneous healing (control). Histology/histomorphometry was performed after 6 months of healing.
The horizontal bucco-palatal width of the alveolar ridge was significantly greater at test sites than at control sites. The amount of mineralized tissue was greater at test sites (57.8% ± 11.1%) than at control sites (28.9% ± 8.5%), while the amount of connective tissue was significantly greater at control sites (41.7% ± 6.4%) than at test sites (19.6% ± 9.2%). No significant difference was found between sites in terms of basic multicellular units and bone marrow. Residual β-TCP at test sites was 5.8% ± 3.2%.
Grafting with tunnel β-TCP block significantly limited the resorption of the alveolar ridge at extraction sockets missing the buccal bone compared with sites left to heal spontaneously, even after 6-month follow-up.
本研究旨在评估在缺失颊侧骨壁的拔牙窝中植入隧道β-TCP 块 6 个月后的组织学结果。
在先前一项关于犬类的研究中，隧道β-磷酸三钙（β-TCP）块由随机组织的隧道形β-TCP 陶瓷制成，在缺失颊侧骨的拔牙窝中用于牙槽嵴保存，具有 2 个月的愈合时间，结果显示该材料很有前景。
在 6 只比格犬中，上颌第一前磨牙被拔出，颊侧骨被手术切除，以创建 4mm（近远中向）×5mm（根尖-冠向）×4mm（颊-腭向）的骨缺损。因此，缺失颊侧骨板的拔牙窝被植入隧道β-TCP 块（实验组）或不植入任何材料作为自然愈合对照（对照组）。在愈合 6 个月后进行组织学/组织形态计量学检查。
实验组的牙槽嵴水平颊腭宽度明显大于对照组。实验组的矿化组织量（57.8%±11.1%）大于对照组（28.9%±8.5%），而对照组的结缔组织量（41.7%±6.4%）明显大于实验组（19.6%±9.2%）。实验组和对照组在基本多细胞单位和骨髓方面无显著差异。实验组的残留β-TCP 为 5.8%±3.2%。
与自然愈合相比，即使在 6 个月的随访后，隧道β-TCP 块的植入显著限制了缺失颊骨的拔牙窝牙槽嵴的吸收。
